A case report of late-onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review

A case report of late-onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review

Context and Objectives: Interferon Beta (IFNβ) is a well-established first-line treatment for patients with multiple sclerosis (RRMS) and remains the most represented agent in sclerosis. Atypical hemolytic uremic syndrome (AHUS) represents a rare but serious adverse effect (AE) that can occur even after many years from the beginning of IFNβ therapy. ECULIZUMAB is currently approved for the treatment of Ahus and recently for the NEUROMYELITE OPTICA SPECTRUM SPECTRUM (NMOSD) with Aquaporin-4 antibodies (AQP4-IGG). In this article, we report the case of the appearance of IFNβ-related IFNβ experienced by an MS patient and we briefly examine the literature on this subject.

Methods: We conducted a systematic review of literature using PubMed and we conducted a retrospective analysis of RRMS patients who received IFNβ-1A in our center and developed thrombotic microangiopathy (TMA). From this search, we have identified only one patient.
Results: In the published literature, we have identified 24 member patients who have received the IFNβ as a treatment modifying the disease (DMT), then developed thrombotic microangiopathy with kidney injury. The Ahus was diagnosed in 6, all IFNβ-1a received and the last appearance was after 15 years. We report a case of a 39-year-old man who has assumed IFNβ-1A since 1999. In July 2018, he has developed an Ahus related to IFNβ. After the failure of the plasma exchange, it has undergone an Eculizumab, with an improvement in the glomerular filtration rate and without new signs of MS activity.

Conclusion: To our knowledge, this case represents the last appearance of IFNβ-related Ahus in patients with SEP. So far, there are no literary reports on the possibility of reintroducing a DMT as a complementary therapy to Eculizumab.

 

Effectiveness of interferon pegylated monotherapy in the treatment of chronic infection of virus hepatitis: a meta-analysis

An HDV chronic infection is often associated with an aggressive form of liver disease with respect to chronic mono-infection of HBV. However, chronic HDV treatment is difficult because there is currently no approved scheme for affected patients. While standard interferon with / without nucleos (t) IDE analogs were lower than pegylated interferon (peginterferon) as HDV treatment based on some randomized clinical trials. This meta-analysis will summarize the results of studies on the effectiveness of peginterferon as an HDV treatment plan. An electronic search was performed using PubMed databases, Cochrane Library, Research Door and Medline.

Studies involving patients who received peginterfer therapy for at least 48 weeks and followed for 24 weeks after therapy were included. All analyzes were conducted using Review Manager 5.3 designed for Cochrane Critics. The main efficiency endpoint was the virological response (VR) or HDV-RNA negativity at the end of the tracking period, while the endpoints of secondary efficiency were a biochemical response (BR or a clearance of ALT and an HBSAG authorization with seroconversion at the end of the follow-up period. The data has been summarized by 13 relevant studies with a total of 475 patients treated with PEGINTERFERON ALPHA-2A or -2B.

At the end of the post-treatment of 24 weeks, the grouped RV was carried out in 29% of patients with 95% of CI [24%; 34%], BR was reached in 33% of patients [95% CI 27%; 40%] and HBSAC clearance with anti-HBS seroconversion was obtained in 1% of patients with 95% CI [-0.02; 0.05]. In conclusion, this study showed that peginterferon has limited efficacy in HDV treatment, since a third of patients with chronic HDV reached viral clearance and standard Alt levels. In addition, HBSAG clearance with anti-HBS seroconversion has rarely been observed in patients with chronic HDV.

 A case report of late-onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review
A case report of late-onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review

New perspectives on the persistence of hepatitis D: the role of the response of interferon and implications for future therapies

Chronic Hepatitis (CHD), a global health problem, manifests itself as the most serious form of viral hepatitis. The causative agent, the hepatitis D virus (HDV), is the smallest known human virus reproduces its RNA genome with a circular slide in the hepatocyte core. HDV requires hepatitis B virus coded envelope proteins (HBV) for diffusion and NOVO cell input. However, HDV can also spread through cell division. After the NTCP mediated input in hepatocytes, the replica intermediates of HDV RNA are detected by the MDA5 pattern recognition receiver, resulting in an induction IFN-β / λ. This response from the IFN strongly suppresses the spread of HDV genomes with mediation by cell division, but only slightly affects RNA replication HDV in hepatocytes already infected, at rest. In patients, the mono-therapy with IFN-α / λ shows efficiency but rarely leads to an HDV authorization.

Recent molecular information on key determinants of HDV persistence and accelerated development of specifically acting antivirals interfering with the replication cycle, opens a new promising therapeutic perspective. In this report, we soon summarize our knowledge about the replication / persistence of HDV and newly discovered HDV agents, HDV interaction with IFN response and its consequences for persistence. Finally, we discuss the possible role of IFNS in combination with new upcoming therapies for HDV healing. Multiple sclerosis (MS) is an inflammatory self-immunoum disorder in the human central nervous system. The recombinant beta interferon (IFN-β) decreases the number of relapses and repels the progression of the disability of the sp.

Genomic DNA from Human Tumor Cell Line: MCF 7

D1255830 100 ug
EUR 291.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Human Tumor Cell Line: Raji

P1255840 1 mg
EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Tumor Cell Line: Raji

P3255840 0.1 mg
EUR 342
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Human Tumor Cell Line: Raji

R1255840-50 50 ug
EUR 232.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Breast

D2235086 2 ug
EUR 985.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Colon

D2235090 2 ug
EUR 985.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Lung

D2235152 2 ug
EUR 985.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Pancreas

D2235188 2 ug
EUR 985.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Stomach

D2235248 2 ug
EUR 985.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Uterus

D2235274 2 ug
EUR 985.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human Genomic DNA

BIO-35025 500µl @ 200ng/µl Ask for price

Human Genomic DNA 

X11000-1 0.2 ml
EUR 235.4

Human Genomic DNA 

X11000
  • Ask for price
  • EUR 235.40
  • 0.2 ml
  • 0.2 ml

96 Well Breast Tumor Genomic DNA Plate

D8235086-1 1 plate
EUR 379.2

96 Well Colon Tumor Genomic DNA Plate

D8235090-1 1 plate
EUR 379.2

96 Well Lung Tumor Genomic DNA Plate

D8235152-1 1 plate
EUR 379.2

96 Well Stomach Tumor Genomic DNA Plate

D8235248-1 1 plate
EUR 379.2

Genomic DNA - Human Male

D1234999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Human Female

D1234999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human Brain Genomic DNA  

X11001-1 10 ul
EUR 77

Human Brain Genomic DNA  

X11001
  • Ask for price
  • EUR 77.00
  • 10 µg
  • 10 ul

Genomic DNA Kit

20-abx098076
  • EUR 526.80
  • EUR 292.80
  • 200 rxns
  • 50 rxns

TCR Activator - Raji Cell Line

60556 2 vials
EUR 11095
Description: Recombinant Raji cell expressing an engineered T cell receptor (TCR) activator._x000D_

Cas9-Expressing Raji Cell Line

78156 2 vials
EUR 6500
Description: This cell line is a clonal derivative from the Cas9-Expressing Raji Cell Pool (BPS Bioscience, #78071). It was generated by limiting dilution of the original pool and isolation of individual clones, which were screened based on Cas9 expression to obtain a high-expressing cell line. The expressed Cas9 protein includes a C-terminal FLAG tag.

Firefly Luciferase Raji Cell Line

78622 2 vials
EUR 2045
Description: Recombinant Raji cells constitutively expressing firefly (Photinus pyralis) luciferase under the control of a CMV promoter.

Raji Cell Slide

17-007 1 pack
EUR 216.6
Description: Raji (B lymphocyte; Burkitt's lymphoma)

Raji Cell Slide

RF10002-04 1 pack
EUR 216.6
Description: Raji (B lymphocyte; Burkitt's lymphoma)

Genomic DNA from Human Tumor Tissue: Breast Tumor, from a single donor

D1235086 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Colon Tumor, from a single donor

D1235090 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Esophagus Tumor, from a single donor

D1235106 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Kidney Tumor, from a single donor

D1235142 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Liver Tumor, from a single donor

D1235149 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Lung Tumor, from a single donor

D1235152 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Ovary Tumor, from a single donor

D1235183 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Rectum Tumor, from a single donor

D1235206 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Stomach Tumor, from a single donor

D1235248 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Thyroid Tumor, from a single donor

D1235265 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Uterus Tumor, from a single donor

D1235274 50 ug
EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Mammalian Cell Genomic DNA Isolation Kit

K967-100 each
EUR 457.2

Genomic DNA - Mouse Male

D1334999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Mouse Female

D1334999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rat Male

D1434999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rat Female

D1434999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Dog Male

D1734999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Dog Female

D1734999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rabbit Male

D1834999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rabbit Female

D1834999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Porcine Male

D1934999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Porcine Female

D1934999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Bovine Male

D1B34999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Bovine Female

D1B34999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Chicken Male

D1C34999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Chicken Female

D1C34999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Hamster Male

D1H34999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Hamster Female

D1H34999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Horse Male

D1O34999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Horse Female

D1O34999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA Isolation Kit

55R-1362 50 assays
EUR 462
Description: Genomic DNA Isolation Kit for use in the research laboratory

Blood Genomic DNA Kit

abx098868-50rxns 50 rxns
EUR 326.4

Plant Genomic DNA Kit

20-abx098077
  • EUR 493.20
  • EUR 276.00
  • 200 rxns
  • 50 rxns

Bacteria Genomic DNA Kit

20-abx098080
  • EUR 126.00
  • EUR 292.80
  • 2 rxns
  • 50 rxns

Micro Genomic DNA Kit

20-abx098242
  • EUR 126.00
  • EUR 393.60
  • 2 rxns
  • 50 rxns

Plant Genomic DNA Kit

abx294004-50preps 50 preps
EUR 477.6

Animal Genomic DNA Kit

abx294005-100preps 100 preps
EUR 627.6

Animal Genomic DNA Kit

abx294005-50preps 50 preps
EUR 477.6

Genomic DNA Isolation Kit

K2118-50 50 assays
EUR 385.2

Soil Genomic DNA Kit

K1411-250 each
EUR 673.2

Soil Genomic DNA Kit

K1411-50 each
EUR 379.2

Insect Genomic DNA Kit

K1412-250 each
EUR 673.2

Insect Genomic DNA Kit

K1412-50 each
EUR 379.2

Mollusc Genomic DNA Kit

K1413-250 each
EUR 673.2

Mollusc Genomic DNA Kit

K1413-50 each
EUR 379.2

Yeast Genomic DNA Kit

K1414-250 each
EUR 673.2

Yeast Genomic DNA Kit

K1414-50 each
EUR 379.2

Fungal Genomic DNA Kit

K1415-250 each
EUR 673.2

Fungal Genomic DNA Kit

K1415-50 each
EUR 379.2

Genomic DNA Isolation Kit

K281-50 each
EUR 326.4

FFPE and Frozen Matching Pair Genomic DNA: Human Tumor Tissue: Breast

D8235086-FP 2 x 2 ug
EUR 2348.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE and Frozen Matching Pair Genomic DNA: Human Tumor Tissue: Colon

D8235090-FP 2 x 2 ug
EUR 2348.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE and Frozen Matching Pair Genomic DNA: Human Tumor Tissue: Lung

D8235152-FP 2 x 2 ug
EUR 2348.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE and Frozen Matching Pair Genomic DNA: Human Tumor Tissue: Stomach

D8235248-FP 2 x 2 ug
EUR 2487.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Fully CpG Methylated Human Genomic DNA

X10000 10 µg/100 µl Ask for price

Raji cells

C0003009 One Frozen vial
EUR 546

Raji Lysate

RF10001-06 0.1 mg
EUR 229.2
Description: Raji lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The Raji lysate was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Genomic DNA - Cynomolgus Monkey Male

D1534999-Cy-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Cynomolgus Monkey Female

D1534999-Cy-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rhesus Monkey Male

D1534999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rhesus Monkey Female

D1534999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Guinea Pig Male

D1G34999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Guinea Pig Female

D1G34999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA Extraction and Purification

EP10012 100 Tests
EUR 606

FFPE Tissue Genomic DNA Kit

abx098866-50rxns 50 rxns
EUR 326.4

Plant Genomic DNA extraction buffer

20-abx098075
  • EUR 343.20
  • EUR 126.00
  • 100 ml
  • 1.2 ml

Marine Animal Genomic DNA Kit

20-abx098079
  • EUR 126.00
  • EUR 292.80
  • 2 rxns
  • 50 rxns

ISOLATE II Genomic DNA Kit

BIO-52065 10 preps Ask for price

ISOLATE II Genomic DNA Kit

BIO-52066 50 preps Ask for price

ISOLATE II Genomic DNA Kit

BIO-52067 250 preps Ask for price

Genomic DNA Extraction KitAnimal Tissue

FYG102-100P 100 Preps Ask for price

Genomic DNA Extraction KitAnimal Tissue

FYG102-300P 300 Preps Ask for price

Genomic DNA Extraction KitAnimal Tissue

FYG102-50P 50 Preps Ask for price

Genomic DNA Extraction Maxi KitPlant

FYG104-10P 10 Preps Ask for price

Genomic DNA Extraction Maxi KitPlant

FYG104-25P 25 Preps Ask for price

AccuRT Genomic DNA Removal Kit

G488 200 Reactions
EUR 98.4

Zenoquick Genomic DNA Purification Kit

Z2003-200 200 preps
EUR 757.2

Zenoprep Genomic DNA Purification Kit

Z2004-400 400 preps
EUR 660

Sera-Xtracta Genomic DNA Kit

29429140 EACH
EUR 380.76

Bacterial Genomic DNA Isolation Kit

K309-100 each
EUR 451.2

Cas9-Expressing Raji cell pool

78071 2 million cells
EUR 795
Description: Cas9 (Streptococcus pyogenes CRISPR associated protein 9) is an endonuclease enzyme that, when recruited to a specific DNA sequence by the sgRNA (single guide RNA), introduces a double stranded break into the DNA. This double stranded break is repaired in mammalian cells either through Non-Homologous End Joining or Homologous Recombination. Non-Homologous End Joining often results in the deletion or insertion of several base pairs at the cut site, which, when resulting in a frameshift, causes the functional inactivation of the targeted gene. Cas9-expressing Raji cells can be transduced or electroporated with sgRNA targeting a gene of interest to quickly generate knock-out cell pools or cell lines.

Cell & tissue genomic DNA extraction and purification kit

K1442-100 each
EUR 679.2

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 87.6
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB 1/pk
EUR 84
Description: Bioscience Mol Bio; DNA Ladder

Rapid Bacteria Genomic DNA Isolation Kit

BS8225 50Preps
EUR 91.97

Rapid Yeast Genomic DNA Extraction Kit

BS8227 50Preps
EUR 91.97

Rapid Blood Genomic DNA Extraction Kit

BT4782 50Preps
EUR 91.97

Genomic DNA Kit (No RNase A)

20-abx098862
  • EUR 477.60
  • EUR 276.00
  • 200 rxns
  • 50 rxns

Rapid Animal Genomic DNA Extraction Kit

AT4780 10Preps
EUR 82.84

Rapid Animal Genomic DNA Extraction Kit

AT4781 50Preps
EUR 151.36

Rapid Animal Genomic DNA Extraction Kit

AT4782 250preps
EUR 425.4

Rapid Fungal Genomic DNA Isolation Kit

FT71415 50Preps
EUR 91.97

Genomic DNA Extraction Mini KitPlant Tissue

FYG103-100P 100 Preps Ask for price

Easy3-Plant Genomic DNA Isolation Kit

FYG503-100P 100 Preps Ask for price

Easy3-Plant Genomic DNA Isolation Kit

FYG503-500P 500 Preps Ask for price

Nucleon BACC3 Genomic DNA Extraction Kit

RPN8512 EACH
EUR 409.26

Plant Tissue Genomic DNA Isolation Kit

K316-100 each
EUR 451.2

Raji Membrane Lysate

XBL-10443 0.1 mg
EUR 619.8
Description: Raji (Human lymphoma; B lymphoma) cell membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The Raji (Human lymphoma; B lymphoma) cell was frozen in liquid nitrogen immediately after excision and then stored at -70ºC. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated Raji (Human lymphoma; B lymphoma) cell membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated Raji (Human lymphoma; B lymphoma) cell membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

FFPE Genomic DNA - Human Adult Normal Tissue: Colon

D2234090 2 ug
EUR 718.8
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Adult Normal Tissue: Liver

D2234149 2 ug
EUR 718.8
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Adult Normal Tissue: Lung

D2234152 2 ug
EUR 718.8
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Adult Normal Tissue: Pancreas

D2234188 2 ug
EUR 718.8
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

VAHTS Human Genomic DNA Quantification and QC Kit

NQ201 300 rxn
EUR 690

Human Raji (Burkitt's Lymphoma) lysate

HCL-1207 1 mg
EUR 628.8

Genomic DNA from Mouse Normal Tissue: Brain

D1334035 100 ug
EUR 338.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Mouse Normal Tissue: Heart

D1334122 100 ug
EUR 338.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

However, up to 50% of patients treated with interferon beta are continuing to live relapses and / or aggravate disability. Simple nucleotide polymorphisms of different genes have been known to show significant associations with a response to IFN-β in patients with SEP. In the current work, we examined the potential role of the genes of TrainR1 and GRIA3 genes on the response to IFN-β therapy in patients with Iranian MS. The DNA was extracted from blood samples with standard procedures of 73 patients diagnosed with multiple sclerosis that were responded to IFN-β or not.

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