A case report of late-onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review

A case report of late-onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review

Context and Objectives: Interferon Beta (IFNβ) is a well-established first-line treatment for patients with multiple sclerosis (RRMS) and remains the most represented agent in sclerosis. Atypical hemolytic uremic syndrome (AHUS) represents a rare but serious adverse effect (AE) that can occur even after many years from the beginning of IFNβ therapy. ECULIZUMAB is currently approved for the treatment of Ahus and recently for the NEUROMYELITE OPTICA SPECTRUM SPECTRUM (NMOSD) with Aquaporin-4 antibodies (AQP4-IGG). In this article, we report the case of the appearance of IFNβ-related IFNβ experienced by an MS patient and we briefly examine the literature on this subject.

Methods: We conducted a systematic review of literature using PubMed and we conducted a retrospective analysis of RRMS patients who received IFNβ-1A in our center and developed thrombotic microangiopathy (TMA). From this search, we have identified only one patient.
Results: In the published literature, we have identified 24 member patients who have received the IFNβ as a treatment modifying the disease (DMT), then developed thrombotic microangiopathy with kidney injury. The Ahus was diagnosed in 6, all IFNβ-1a received and the last appearance was after 15 years. We report a case of a 39-year-old man who has assumed IFNβ-1A since 1999. In July 2018, he has developed an Ahus related to IFNβ. After the failure of the plasma exchange, it has undergone an Eculizumab, with an improvement in the glomerular filtration rate and without new signs of MS activity.

Conclusion: To our knowledge, this case represents the last appearance of IFNβ-related Ahus in patients with SEP. So far, there are no literary reports on the possibility of reintroducing a DMT as a complementary therapy to Eculizumab.

 

Effectiveness of interferon pegylated monotherapy in the treatment of chronic infection of virus hepatitis: a meta-analysis

An HDV chronic infection is often associated with an aggressive form of liver disease with respect to chronic mono-infection of HBV. However, chronic HDV treatment is difficult because there is currently no approved scheme for affected patients. While standard interferon with / without nucleos (t) IDE analogs were lower than pegylated interferon (peginterferon) as HDV treatment based on some randomized clinical trials. This meta-analysis will summarize the results of studies on the effectiveness of peginterferon as an HDV treatment plan. An electronic search was performed using PubMed databases, Cochrane Library, Research Door and Medline.

Studies involving patients who received peginterfer therapy for at least 48 weeks and followed for 24 weeks after therapy were included. All analyzes were conducted using Review Manager 5.3 designed for Cochrane Critics. The main efficiency endpoint was the virological response (VR) or HDV-RNA negativity at the end of the tracking period, while the endpoints of secondary efficiency were a biochemical response (BR or a clearance of ALT and an HBSAG authorization with seroconversion at the end of the follow-up period. The data has been summarized by 13 relevant studies with a total of 475 patients treated with PEGINTERFERON ALPHA-2A or -2B.

At the end of the post-treatment of 24 weeks, the grouped RV was carried out in 29% of patients with 95% of CI [24%; 34%], BR was reached in 33% of patients [95% CI 27%; 40%] and HBSAC clearance with anti-HBS seroconversion was obtained in 1% of patients with 95% CI [-0.02; 0.05]. In conclusion, this study showed that peginterferon has limited efficacy in HDV treatment, since a third of patients with chronic HDV reached viral clearance and standard Alt levels. In addition, HBSAG clearance with anti-HBS seroconversion has rarely been observed in patients with chronic HDV.

 A case report of late-onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review
A case report of late-onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review

New perspectives on the persistence of hepatitis D: the role of the response of interferon and implications for future therapies

Chronic Hepatitis (CHD), a global health problem, manifests itself as the most serious form of viral hepatitis. The causative agent, the hepatitis D virus (HDV), is the smallest known human virus reproduces its RNA genome with a circular slide in the hepatocyte core. HDV requires hepatitis B virus coded envelope proteins (HBV) for diffusion and NOVO cell input. However, HDV can also spread through cell division. After the NTCP mediated input in hepatocytes, the replica intermediates of HDV RNA are detected by the MDA5 pattern recognition receiver, resulting in an induction IFN-β / λ. This response from the IFN strongly suppresses the spread of HDV genomes with mediation by cell division, but only slightly affects RNA replication HDV in hepatocytes already infected, at rest. In patients, the mono-therapy with IFN-α / λ shows efficiency but rarely leads to an HDV authorization.

Recent molecular information on key determinants of HDV persistence and accelerated development of specifically acting antivirals interfering with the replication cycle, opens a new promising therapeutic perspective. In this report, we soon summarize our knowledge about the replication / persistence of HDV and newly discovered HDV agents, HDV interaction with IFN response and its consequences for persistence. Finally, we discuss the possible role of IFNS in combination with new upcoming therapies for HDV healing. Multiple sclerosis (MS) is an inflammatory self-immunoum disorder in the human central nervous system. The recombinant beta interferon (IFN-β) decreases the number of relapses and repels the progression of the disability of the sp.

Genomic DNA from Human Tumor Cell Line: Jurkat

D1255815 100 ug
EUR 243
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Tumor Cell Line: Raji

C1255840 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Cell Line: K 562

D1255820 100 ug
EUR 243
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Cell Line: MCF 7

D1255830 100 ug
EUR 243
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Human Tumor Cell Line: Raji

P1255840 1 mg
EUR 214
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Membrane Protein from Human Tumor Cell Line: Raji

P3255840 0.1 mg
EUR 285
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Total RNA from Human Tumor Cell Line: Raji

R1255840-50 50 ug
EUR 194
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FFPE Genomic DNA - Human Tumor Tissue: Breast

D2235086 2 ug
EUR 821
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Colon

D2235090 2 ug
EUR 821
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Lung

D2235152 2 ug
EUR 821
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Pancreas

D2235188 2 ug
EUR 821
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FFPE Genomic DNA - Human Tumor Tissue: Stomach

D2235248 2 ug
EUR 821
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FFPE Genomic DNA - Human Tumor Tissue: Uterus

D2235274 2 ug
EUR 821
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Human Genomic DNA

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Human Genomic DNA

X11000 0.2 ml Ask for price
Description: reagents widely cited

96 Well Breast Tumor Genomic DNA Plate

D8235086-1 1 plate
EUR 316

96 Well Colon Tumor Genomic DNA Plate

D8235090-1 1 plate
EUR 316

96 Well Lung Tumor Genomic DNA Plate

D8235152-1 1 plate
EUR 316

96 Well Stomach Tumor Genomic DNA Plate

D8235248-1 1 plate
EUR 316

Genomic DNA - Human Male

D1234999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

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D1234999-G02 100 ug
EUR 188
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Human Brain Genomic DNA

X11001 10 µg Ask for price
Description: kits suitable for this type of research

Genomic DNA Kit

20-abx098076
  • EUR 439.00
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  • 200 rxns
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Genomic DNA from Human Tumor Tissue: Breast Tumor, from a single donor

D1235086 50 ug
EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Colon Tumor, from a single donor

D1235090 50 ug
EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Esophagus Tumor, from a single donor

D1235106 50 ug
EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

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D1235142 50 ug
EUR 446
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EUR 446
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EUR 446
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Genomic DNA from Human Tumor Tissue: Ovary Tumor, from a single donor

D1235183 50 ug
EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

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D1235206 50 ug
EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Stomach Tumor, from a single donor

D1235248 50 ug
EUR 446
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Genomic DNA from Human Tumor Tissue: Thyroid Tumor, from a single donor

D1235265 50 ug
EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Human Tumor Tissue: Uterus Tumor, from a single donor

D1235274 50 ug
EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Mammalian Cell Genomic DNA Isolation Kit

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EUR 381

Plant Genomic DNA Kit

20-abx098077
  • EUR 411.00
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Bacteria Genomic DNA Kit

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Micro Genomic DNA Kit

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  • EUR 105.00
  • EUR 328.00
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Blood Genomic DNA Kit

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EUR 272
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Plant Genomic DNA Kit

abx294004-50preps 50 preps
EUR 398
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Animal Genomic DNA Kit

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Animal Genomic DNA Kit

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Genomic DNA Isolation Kit

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EUR 385
Description: Genomic DNA Isolation Kit for use in the research laboratory

Soil Genomic DNA Kit

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EUR 561

Soil Genomic DNA Kit

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EUR 316

Insect Genomic DNA Kit

K1412-250
EUR 561

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EUR 316

Mollusc Genomic DNA Kit

K1413-250
EUR 561

Mollusc Genomic DNA Kit

K1413-50
EUR 316

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K1414-250
EUR 561

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EUR 561

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Genomic DNA Isolation Kit

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EUR 321

Genomic DNA Isolation Kit

K281-50
EUR 272

Genomic DNA - Mouse Male

D1334999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

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D1334999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rat Male

D1434999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

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D1434999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Dog Male

D1734999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Dog Female

D1734999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rabbit Male

D1834999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rabbit Female

D1834999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Porcine Male

D1934999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

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D1934999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Bovine Male

D1B34999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Bovine Female

D1B34999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Chicken Male

D1C34999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Chicken Female

D1C34999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Hamster Male

D1H34999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Hamster Female

D1H34999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Horse Male

D1O34999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Horse Female

D1O34999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA Extraction Kit

K5016005 1 kit
EUR 329

Raji cells

C0003009 One Frozen vial
EUR 455

FFPE and Frozen Matching Pair Genomic DNA: Human Tumor Tissue: Breast

D8235086-FP 2 x 2 ug
EUR 1957
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE and Frozen Matching Pair Genomic DNA: Human Tumor Tissue: Colon

D8235090-FP 2 x 2 ug
EUR 1957
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE and Frozen Matching Pair Genomic DNA: Human Tumor Tissue: Lung

D8235152-FP 2 x 2 ug
EUR 1957
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE and Frozen Matching Pair Genomic DNA: Human Tumor Tissue: Stomach

D8235248-FP 2 x 2 ug
EUR 2073
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Fully CpG Methylated Human Genomic DNA

X10000 10 µg/100 µl Ask for price
Description: The best epigenetics products

ISOLATE II Genomic DNA Kit

BIO-52065 10 preps Ask for price

ISOLATE II Genomic DNA Kit

BIO-52066 50 preps Ask for price

ISOLATE II Genomic DNA Kit

BIO-52067 250 preps Ask for price

Genomic DNA Extraction KitAnimal Tissue

FYG102-100P 100 Preps Ask for price

Genomic DNA Extraction KitAnimal Tissue

FYG102-300P 300 Preps Ask for price

Genomic DNA Extraction KitAnimal Tissue

FYG102-50P 50 Preps Ask for price

Genomic DNA Extraction Maxi KitPlant

FYG104-10P 10 Preps Ask for price

Genomic DNA Extraction Maxi KitPlant

FYG104-25P 25 Preps Ask for price

AccuRT Genomic DNA Removal Kit

G488 200 Reactions
EUR 82

Genomic DNA Extraction and Purification

EP10012 100 Tests
EUR 505

Plant Genomic DNA extraction buffer

20-abx098075
  • EUR 286.00
  • EUR 105.00
  • 100 ml
  • 1.2 ml
  • Shipped within 5-10 working days.

Marine Animal Genomic DNA Kit

20-abx098079
  • EUR 105.00
  • EUR 244.00
  • 2 rxns
  • 50 rxns
  • Shipped within 5-10 working days.

FFPE Tissue Genomic DNA Kit

abx098866-50rxns 50 rxns
EUR 272
  • Shipped within 5-10 working days.

Genomic DNA - Cynomolgus Monkey Male

D1534999-Cy-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Cynomolgus Monkey Female

D1534999-Cy-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rhesus Monkey Male

D1534999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rhesus Monkey Female

D1534999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Guinea Pig Male

D1G34999-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Guinea Pig Female

D1G34999-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Bacterial Genomic DNA Isolation Kit

K309-100
EUR 376

Zenoquick Genomic DNA Purification Kit

Z2003-200 200 preps
EUR 631

Zenoprep Genomic DNA Purification Kit

Z2004-400 400 preps
EUR 550

Cell & tissue genomic DNA extraction and purification kit

K1442-100
EUR 566

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 73
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB 1/pk
EUR 70
Description: Bioscience Mol Bio; DNA Ladder

Human Raji (Burkitt's Lymphoma) lysate

HCL-1207 1 mg
EUR 524

Genomic DNA Extraction Mini KitPlant Tissue

FYG103-100P 100 Preps Ask for price

Easy3-Plant Genomic DNA Isolation Kit

FYG503-100P 100 Preps Ask for price

Easy3-Plant Genomic DNA Isolation Kit

FYG503-500P 500 Preps Ask for price

Genomic DNA Kit (No RNase A)

20-abx098862
  • EUR 398.00
  • EUR 230.00
  • 200 rxns
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Plant Tissue Genomic DNA Isolation Kit

K316-100
EUR 376

Rapid Fungal Genomic DNA Isolation Kit

FT71415 50Preps
EUR 76.64
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Fungi

Rapid Animal Genomic DNA Extraction Kit

AT4780 10Preps
EUR 69.03
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Animal

Rapid Animal Genomic DNA Extraction Kit

AT4781 50Preps
EUR 126.13
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Animal

Rapid Animal Genomic DNA Extraction Kit

AT4782 250preps
EUR 354.5
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Animal

Rapid Bacteria Genomic DNA Isolation Kit

BS8225 50Preps
EUR 76.64
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Bacteria

Rapid Yeast Genomic DNA Extraction Kit

BS8227 50Preps
EUR 76.64
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Yeast

Rapid Blood Genomic DNA Extraction Kit

BT4782 50Preps
EUR 76.64
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Blood

FFPE Genomic DNA - Human Adult Normal Tissue: Colon

D2234090 2 ug
EUR 599
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Adult Normal Tissue: Liver

D2234149 2 ug
EUR 599
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Adult Normal Tissue: Lung

D2234152 2 ug
EUR 599
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Adult Normal Tissue: Pancreas

D2234188 2 ug
EUR 599
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

VAHTS Human Genomic DNA Quantification and QC Kit

NQ201 300 rxn
EUR 575

CytoSelect Clonogenic Tumor Cell Isolation Kit (5 preps)

CBA-155 5 preps
EUR 798
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis.

Blood Genomic DNA Extraction Mini Kit (100prep)

FABGK-100 100 preps
EUR 165

Blood Genomic DNA Extraction Mini Kit (300prep)

FABGK-300 300 preps
EUR 266

FavorPrep Genomic DNA Clean-Up Kit (50prep)

FAGDC-001 50 preps
EUR 129

FavorPrep Genomic DNA Clean-Up Kit (200prep)

FAGDC-001-1 200 preps
EUR 204

Plant Genomic DNA Extraction Mini Kit (50prep)

FAPGK-001 50 preps
EUR 158

Plant Genomic DNA Extraction Mini Kit (100prep)

FAPGK-001-1 100 preps
EUR 204

Plant Genomic DNA Extraction Mini Kit (200prep)

FAPGK-001-2 200 preps
EUR 274

Plant Genomic DNA Extraction Maxi Kit (10prep)

FAPGK-002 10 preps
EUR 201

Plant Genomic DNA Extraction Maxi Kit (24prep)

FAPGK-002-1 24 preps
EUR 317

However, up to 50% of patients treated with interferon beta are continuing to live relapses and / or aggravate disability. Simple nucleotide polymorphisms of different genes have been known to show significant associations with a response to IFN-β in patients with SEP. In the current work, we examined the potential role of the genes of TrainR1 and GRIA3 genes on the response to IFN-β therapy in patients with Iranian MS. The DNA was extracted from blood samples with standard procedures of 73 patients diagnosed with multiple sclerosis that were responded to IFN-β or not.

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