Impaired interferon-α expression in plasmacytoid dendritic cells in asthma

Impaired interferon-α expression in plasmacytoid dendritic cells in asthma

Background: Activation of the receiver receiver (RV) is involved in the pathogenesis of asthma. The dendritic cells of plasmacytoids (PDCs) are the main interferon-α cells against viruses.

OBJECTIVE: To determine whether asthmatic patients and control topics differ in terms of interferon-α expression in PDCs under TLR-7 or RV stimulation.

Methods: PDCs have been identified in mononuclear cells of BDCA-2 + and HLA-DR + peripheral blood. The interferon-α expression of the PDC was analyzed after the TLR-7 stimulation with or without interleukin (IL-4) / pretreatment IL-13. Interferon-α expression was also analyzed after RV stimulation over periods of 24, 48 or 96 hours with or without pretreatment IL-4. RV detection and molecular typing have been analyzed from throat swabs.

Results: Following the TLR-7 stimulation, the expression of intracellular-α interferon was higher in the PDCs of normal subjects than those of asthmatic patients; However, pretreatment with IL-4 has been demonstrated to reduce this effect. After the stimulation of RV of 48 and 96-H, we observed a noticeable increase in the production of PDC interferon-α in normal subjects, but no asthmatic patients. The basic interferon-α expression in the PDCs and the incidence of the exacerbation of emergency asthma was higher in the 13% of patients identified as rhinovirus + than among their RV counterparts.

Conclusion: Our study discovered that the response to the stimulation of TLR-7 in the PDCs has been compromised and the durability of interferon-α expression to the stimulation of the RV has been reduced in the PDCs of asthmatic patients , which provides additional evidence of the defective innate response and the sub-specificity to RV infection in asthma. The high exacerbating history founded in VR + patients agrees with these conclusions. Additional research is needed for the modulator effect of IL-4 on the PDC stimulated by TLR-7.

Interaction between hepatitis D virus and interferon response

Chronic hepatitis (CHD) is the most serious form of viral hepatitis, rapid growth in liver-related diseases and high levels of hepatocellular carcinoma development. The causal agent, the hepatitis D virus (HDV), contains a small circular genome of the unique mounting RNA RNA (about 1.7 KB) assembling with the HDV antigen to form a complex ribonucleoprotein (RNP). HDV depends on the protein of the hepatitis B envelope (HBV) for the wrapping wrapping and novo hepatocytes; However, its replication of intracellular RNA is autonomous. In addition, HDV can amplify HBV independently by cell division.

The inevitable immune responses, mainly interferon (IFN), are crucial for controlling invasive viruses, while viruses are controlled these responses to promote their spread. Unlike VHB, HDV activates the deep IFN response through the antigen 5 (MDA5) differentiation route. This cellular response effectively removes HDV propagation mediated by cell division and, to a certain extent, the first steps of Novo HDV infection, but only slightly free the replication of RNA in hepatocytes at rest. In this review, we summarize the current knowledge of HDV structure, replication and persistence and then focus on the interaction between the HDV response and the IFN, including the activation of the IFN, the detection, the detection. Antiviral effects and viral countermeasures.

Finally, we discuss crosstalk with HBV. Treatment with anti-PD-1 immunotherapy does not lead to sustainable clinical responses in about 60% of patients with metastatic melanoma. These refractory patients, however, always respond to treatment with tumor (til) and interferon-alpha (IFNA) tumor-infiltration lymphocytes. A combination of TIL, Pegylate-Interferon-Alpha (PEG-IFNA) and Anti-PD-1 should provide safe, feasible and effective therapy in patients with metastatic melanoma, which are refractory to care treatment options.

 Impaired interferon-α expression in plasmacytoid dendritic cells in asthma
Impaired interferon-α expression in plasmacytoid dendritic cells in asthma

MPEG1 / PERFORIN-2 HAPLINUFFACEENCE Pelmicrobialic skin infections associated and considerations on interferon-γ therapy

Introduction: The gene expressed by Macrophage 1 (MPEG1) is extremely expressed in macrophages and other phagocytes. The gene code a bactericidal pores formation, brought perforine-2. Structural, animal and cellular studies have established that perforin-2 facilitates the destruction of phagocyteral microbes on its activation in acidic phasome. Compared to wild type controls, Knockout MPEG1 mice suffer significantly higher mortality rates when challenged by negative or positive gram pathogens. Only four variants of MPEG1 have been functionally functionalized, each in combination with pulmonary infections. Here we note a new variant of MPEG1 nonsense in a patient with a recently described association with persistent polymicrobial skin infections and soft tissues.

Case Description: A young adult woman was evaluated for recurring breast abscesses and cellulite and demonstrated a heterozygous and rare variant in MPEG1 p.tyr430 *. Several courses of broad spectrum antimicrobials and surgical incision and drainage have failed to solve the infection. Functional studies have revealed that the truncation variant has resulted in a considerably reduced capacity of patient’s phagocytes to kill intracellular bacteria. The patient’s derived macrophages responded to gamma interferon (IFN-γ) by considerably increasing MPEG1 expression. The IFN-γ treatment supported bactericidal activity and bactericidal healing and healing of perforin wounds.

Mouse Anti Mouse Cd44 Monoclonal Antibody

CABT-46107MM 0.25 mg
EUR 663

Mouse, Bax Mouse Recombinant Protein, GST

PROTQ07813-1 Regular: 10ug
EUR 317
Description: Bax Mouse Recombinant amino acid 1-171 produced in E.Coli is a single, non-glycosylated polypeptide chain. ;The Mouse Bax is purified by proprietary chromatographic techniques.

Mouse, CD14 Mouse Recombinant Protein, Sf9

PROTP10810-1 Regular: 10ug
EUR 317
Description: CD14 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 357 amino acids (16-366a.a.) and having a molecular mass of 38.3kDa. _x000D_ (Molecular size on SDS-PAGE will appear at approximately 40-57kDa)._x000D_ CD14 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Mouse, GAPDH Mouse Recombinant Protein, Active

PROTP16858-1 Regular: 10ug
EUR 317
Description: GAPDH Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 356 amino acids (1-333a.a.) and having a molecular mass of 38.2kDa.;GAPDH is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Mouse to Mouse HRP Staining System

MTM003 400 Slides
EUR 361

Mouse IgG

31-AM15 10 mg
EUR 215
Description: Purified Mouse IgG

Mouse IgG

31-AM15S 10 mg
EUR 130
Description: Purified Mouse IgG

Mouse IgG1

31C-CH1004 1 mg
EUR 377
Description: Purified Mouse IgG1

Mouse IgG2a

31C-CH1007 1 mg
EUR 377
Description: Purified Mouse IgG2a

Mouse IgG2b

31C-CH1010 1 mg
EUR 365
Description: Purified Mouse IgG2b

Mouse IgG3

31C-CH1013 1 mg
EUR 365
Description: Purified Mouse IgG3

Mouse IgM

31C-CH1025 1 mg
EUR 365
Description: Purified Mouse IgM

Mouse IgG

1265-100
EUR 153

Mouse IgG

1265-1000
EUR 370

GHRF, mouse

5-01202 0.4 x 5mg Ask for price

mCRAMP, mouse

5-01528 4 x 1mg Ask for price

Mouse IgG1

C040307-10mg 10mg
EUR 1790

Mouse IgG1

C040307-1mg 1mg
EUR 607

Mouse IgG2a

C040308-10mg 10mg
EUR 1790

Mouse IgG2a

C040308-1mg 1mg
EUR 607

Mouse IgG2b

C040309-10mg 10mg
EUR 1790

Mouse IgG2b

C040309-1mg 1mg
EUR 607

Mouse IgG3

C040310-10mg 10mg
EUR 1790

Mouse IgG3

C040310-1mg 1mg
EUR 607

Mouse IgM

C040311-10mg 10mg
EUR 1790

Mouse IgM

C040311-1mg 1mg
EUR 607

Mouse IgA

C040312-10mg 10mg
EUR 1790

Mouse IgA

C040312-1mg 1mg
EUR 607

Mouse Serum

abx098261-100L 100 L
EUR 129506

Mouse Serum

20-abx098261
  • EUR 1163.00
  • EUR 272.00
  • 100 ml
  • 10 ml

Mouse Serum

abx098261-5L 5 L
EUR 8833

Mouse Serum

abx098262-1ml 1 ml
EUR 1720

Mouse ; Thymocyte

02-703 100ng
EUR 401
Description: The Mouse ; Thymocyte is available in Europe and for worldwide shipping via Gentaur.

Mouse ; Testis

02-715 100ng
EUR 401
Description: The Mouse ; Testis is available in Europe and for worldwide shipping via Gentaur.

LIF, mouse

MO16102 100 ug
EUR 675

mCherry - Mouse

MO22140 100 ul
EUR 435

Mouse Cardiomyocytes

PC35136 P0 Mouse - Whole Heart Dissociated Cells X2
EUR 1419

Leptin-Mouse

PR27099 200 ug
EUR 191

ADAM10 (Mouse)

GT15079 100 ug
EUR 526

EGF, Mouse

HY-P7067 100ug
EUR 187

LIF, Mouse

HY-P7084 50ug
EUR 533

Adiponectin, Mouse

HY-P7129 50ug
EUR 418

CCL6, Mouse

HY-P7143 10ug
EUR 268

CNTF, Mouse

HY-P7147 10ug
EUR 211

OSM, Mouse

HY-P7275 50ug
EUR 762

Betacellulin, Mouse

HY-P7329 50ug
EUR 612

MIF, Mouse

HY-P7388 10ug
EUR 234

CXCL16, Mouse

HY-P7151 10ug
EUR 268

CXCL3, Mouse

HY-P7153 50ug
EUR 670

Shh, Mouse

HY-P7290 50ug
EUR 567

VEGF165, Mouse

HY-P7312 50ug
EUR 807

DHH, Mouse

HY-P7339 50ug
EUR 497

Mouse IgG

E61I007 1mg
EUR 343

Mouse HSV

EMH0317 96Tests
EUR 521

Mouse HSV

EMH0318 96Tests
EUR 521

Parstatin (mouse)

B5451-1 1 mg
EUR 772

ExoStep Mouse

MOExoS-25-C9 25 test
EUR 537.5

CRAMP (mouse)

H-6526.0001 1.0mg
EUR 273
Description: Sum Formula: C178H302N50O46; CAS# [376364-36-2] net

CRAMP (mouse)

H-6526.0005 5.0mg
EUR 998
Description: Sum Formula: C178H302N50O46; CAS# [376364-36-2] net

Endotrophin (mouse)

H-7382.0100 0.1mg
EUR 383
Description: Sum Formula: C345H520N92O106S7; CAS# [1678414-54-4] net

Endotrophin (mouse)

H-7382.0500 0.5mg
EUR 1438
Description: Sum Formula: C345H520N92O106S7; CAS# [1678414-54-4] net

EGF Mouse

P2558-.1 100 µg
EUR 108

EGF Mouse

P2558-.5 500 µg
EUR 200

EGF Mouse

P2558-1 1 mg
EUR 311

mCRAMP, mouse

SP-88328-1 1 mg
EUR 286

Mouse Monoclonal Anti-Mouse CD11a, Biotin (Clone 8-6.2) (mouse IgG2a)

MCD011A-B 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD11a, FITC (Clone 8-6.2) (mouse IgG2a)

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Mouse Monoclonal Anti-Mouse CD11a, Purified (Clone 8-6.2) (mouse IgG2a)

MCD011A-M 100 ug
EUR 482

Mouse Monoclonal Anti-Mouse CD11a, PE (Clone 8-6.2) (mouse IgG2a)

MCD011A-PE 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD72.1, Biotin (Clone CT-72.1) (mouse IgG2a)

MCD072-B 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD72.1, FITC (Clone CT-72.1) (mouse IgG2a)

MCD072-F 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD72.1, Purified (Clone CT-72.1) (mouse IgG2a)

MCD072-M 100 ug
EUR 482

Mouse Monoclonal Anti-Mouse CD72.1, PE (Clone CT-72.1) (mouse IgG2a)

MCD072-PE 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse/Rat CD81, Biotin (Clone Eat2)(mouse IgG1)

MCD081-B 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse/Rat CD81, FITC (Clone Eat2)(mouse IgG1)

MCD081-F 100 tests
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Mouse Monoclonal Anti-Mouse/Rat CD81, PE (Clone Eat2)(mouse IgG1)

MCD081-PE 100 tests
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Mouse Monoclonal Anti-Mouse/Rat CD81, Purified (Clone Eat2)(mouse IgG1)

MCD081-UL 100 ug
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Mouse Anti Mouse Cd14 Monoclonal Antibody,RPE

CABT-45608MM 100 TEST
EUR 533

Mouse Anti Mouse Cd44 Monoclonal Antibody,RPE

CABT-46109MM 100 TEST
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Mouse Anti Mouse Cd28 Monoclonal Antibody,RPE

CABT-48085MM 100 TEST
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Mouse, Flt3 Ligand Mouse Recombinant Protein, Sf9

PROTP49772-1 Regular: 5ug
EUR 317
Description: Flt3 Ligand produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (27-189 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 169 amino acids and having a molecular mass of 19.3kDa.;Flt3 Ligand shows multiple bands between 18-28kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

Acrp30 Mouse, Adiponectin Mouse Recombinant Protein, HEK

PROTQ60994-2 Regular: 10ug
EUR 317
Description: The Acrp30 Mouse Recombinant is fused with FLAG tag having a total Mw of 26kDa.

Mouse, Resistin Mouse Recombinant Protein, His Tag

PROTQ99P87 Regular: 25ug
EUR 317
Description: Resistin Mouse is manufactured with signal sequence of phage fd (21aa) and C-terminal fusion of flagTag (10aa). Resistin Mouse Recombinant Flag-Tagged Fusion Protein is 13.7 kDa protein containing 93 amino acid residues of the Resistin Mouse and 31 additional amino acid residues - signal sequence of phage fd, flagTag (underlined).

Mouse Anti Mouse Nc1.1 Monoclonal Antibody,RPE

DMABT-54461MM 25 TEST
EUR 429

Mouse APT(Mouse Abnormal prothrombin) ELISA Kit

EM1857 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Mouse Monoclonal Anti-Mouse Myeloperoxidase (MPO) IgG

MPO12-M 100 ul
EUR 482

Mouse to Mouse HRP (DAB) Staining System

MTM001 70 Slides
EUR 157

Mouse to Mouse HRP (AEC) Staining System

MTM002 70 Slides
EUR 157

Mouse to Mouse Alk-Phos Staining System

MTM005 400 Slides
EUR 361

Mouse monoclonal Anti-rat/mouse lactoferrin IgG

LTF15-M 100 ul
EUR 482

Mouse Monoclonal Anti-Mouse CD5 (Ly 1.2), Biotin (Clone CG16) (mouse IgG2b)

MCD005-B 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD5 (Ly 1.2), FITC (Clone CG16) (mouse IgG2b)

MCD005-F 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD5 (Ly 1.2), PE (Clone CG16) (mouse IgG2b)

MCD005-PE 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD160 mAb, Biotin, (clone CNX46-3), (mouse IgG2bk)

MCD160-B 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD160 mAb, FITC, (clone CNX46-3), (mouse IgG2bk)

MCD160-F 50 Tests
EUR 408

Mouse Monoclonal Anti-Mouse CD160 mAb, Purified, (clone CNX46-3), (mouse IgG2bk)

MCD160-M 100 ug
EUR 482

Mouse Monoclonal Anti-Mouse CD160 mAb, PE, (clone CNX46-3), (mouse IgG2bk)

MCD160-PE 50 tests
EUR 347

Mouse Monoclonal Anti-Mouse CD5 (Ly 1.2), No Azide (Clone CG16) (mouse IgG2b)

MCD005-M 100 Tests
EUR 482

Mouse Anti-Mouse TIGIT Monoclonal antibody, clone 1G9

CABT-L4298-1mg 1 mg
EUR 897

Mouse Anti-Mouse TIGIT Monoclonal antibody, clone 1G9

CABT-L4298-5mg 5 mg
EUR 2405

Mouse Anti-Mouse CD22 Monoclonal antibody, clone Cy34.1

CABT-L4309-1mg 1 mg
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Mouse Anti-Mouse CD22 Monoclonal antibody, clone Cy34.1

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Mouse Anti-Mouse NK1.1 Monoclonal antibody, clone PK136

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Mouse Anti-Mouse NK1.1 Monoclonal antibody, clone PK136

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Mouse Anti-Mouse CD45.2 Monoclonal antibody, clone 104.2

CABT-L4528-1mg 1 mg
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Mouse Anti-Mouse CD45.2 Monoclonal antibody, clone 104.2

CABT-L4528-5mg 5 mg
EUR 2405

Mouse Anti Mouse Cd28 Monoclonal Antibody,Low Endotoxin

CABT-48083MM 0.5 mg
EUR 881

Mouse IgG1 (FITC) / Mouse IgG1 (RPE) Isotype Control

abx405001-50tests 50 tests
EUR 634

Mouse IgG2a (FITC) / Mouse IgG2a (RPE) Isotype Control

abx405002-50tests 50 tests
EUR 620

Mouse IgG1 (FITC) / Mouse IgG2a (RPE) Isotype Control

abx405003-50tests 50 tests
EUR 620

Mouse IgG1 (FITC) / Mouse IgG1 (RPE) Isotype Control

abx405005-100tests 100 tests
EUR 620

Pancreas Dissociation System 5 (Acinar, mouse parotid), Mouse

4-20375 ea Ask for price

Acrp30 Mouse, Adiponectin Mouse Recombinant Protein, Trimeric form

PROTQ60994 Regular: 10ug
EUR 317
Description: Trimeric form of Acrp30 Mouse was expressed in HEK293 cells.;The cysteine 39 was replaced with alanine (C39A) 9. mAd-C39A can only form trimer, but not hexamer or HMW form.

Acrp30 Mouse, Adiponectin Mouse Recombinant Protein, His Tag

PROTQ60994-3 Regular: 25ug
EUR 317
Description: The Adiponectin Mouse is created as a recombinant protein with a 21 a.a N-terminal fusion of His Tag. The Adiponectin His-Tagged Fusion Protein, produced in E. coli, is a 27.2kDa protein containing 251 amino acid residues of the Acrp30 Mouse, 18-247 amino acids.

IL3 Mouse, Interleukin-3 Mouse Recombinant Protein, sf9

PROTP01586-1 Regular: 5ug
EUR 317
Description: IL3 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 148 amino acids (27-166 a.a.) and having a molecular mass of 16.7kDa (Migrates at 18-28kDa on SDS-PAGE under reducing conditions).;IL3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

CTSB Mouse, Cathepsin-B Mouse Recombinant Protein, Active

PROTP10605-1 Regular: 10ug
EUR 317
Description: CTSB Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 330 amino acids (18-339a.a.) and having a molecular mass of 36.4kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa)._x000D_ CTSB is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

CST3 Mouse, Cystatin-C Mouse Recombinant Protein, sf9

PROTP21460-2 Regular: 10ug
EUR 317
Description: CST3 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 126 amino acids (21-140a.a.) and having a molecular mass of 14.2kDa. (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).;CST3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

CST3 Mouse, Cystatin-C, Recombinant Protein Mouse Active

PROTP21460-3 Regular: 10ug
EUR 317
Description: CST3 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 126 amino acids (21-140 a.a.) and having a molecular mass of 14.2kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).;CST3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

CST3 Mouse, Cystatin-C Mouse Recombinant Protein, Active

PROTP21460-4 Regular: 10ug
EUR 317
Description: CST3 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 126 amino acids (21-140 a.a.) and having a molecular mass of 14.2kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).;CST3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Mouse Anti Mouse Nc1.1 Monoclonal Antibody,Azide Free

DMABT-54458MM 1 mg
EUR 1261

Normal Mouse Serum

88-NM35 50 ml
EUR 516
Description: Normal Mouse Serum

Normal Mouse Serum

88R-1002 5 ml
EUR 203
Description: Normal Mouse Serum which has been lipid extracted and dialyzed against 10 mM Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Mouse Transferrin antibody

70R-TG002 1 mg
EUR 219
Description: Affinity purified Goat polyclonal Mouse Transferrin antibody

APRIL, Mouse Recombinant

7118-10
EUR 196

APRIL, Mouse Recombinant

7118-50
EUR 675

CD274, mouse recombinant

7311-100
EUR 370

IL18, mouse recombinant

7326-100
EUR 566

IL18, mouse recombinant

7326-50
EUR 365

LGALS8, mouse recombinant

7366-50
EUR 370

Apotransferrin, Mouse Plasma

7540-1000
EUR 272

PCAF, mouse recombinant

7556-10 - Ask for price

FTO, mouse recombinant

7558-10
EUR 294

RBP4, mouse recombinant

7565-10
EUR 311

RBP4, mouse recombinant

7565-50
EUR 865

PEDF, mouse recombinant

7572-10
EUR 387

mouse Splunc2 Antibody

BF0461 200ul
EUR 376
Description: mouse Splunc2 antibody detects endogenous levels of total mouse Splunc2.

CLDN6 Mouse mAb

BF8001 100ul
EUR 304
Description: Affinity-chromatography.

Fibronectin Mouse mAb

BF9010 200ul
EUR 376
Description: The Fibronectin antibody can recognize endogenous Fibronectin proteins.

eIF4A1 Mouse mAb

BF9011 100 ug
EUR 438

HSP70 Mouse mAb

BF9012 200ul
EUR 376
Description: The HSP70 mouse monoclonal antibody can detect endogenous HSP70 proteins.

CK7 Mouse mAb

BF9202 100 ug
EUR 438

XRCC4 Mouse mAb

BF9204 100 ug
EUR 438

Oct1 Mouse mAb

BF9205 100 ug
EUR 438

CD16 Mouse mAb

BF9207 100 ug
EUR 438

PCNA Mouse mAb

BF9209 100 ug
EUR 438

MAP2 Mouse mAb

BF9214 100 ug
EUR 438

GFAP Mouse mAb

BF9215 100 ug
EUR 438

Transferrin Mouse mAb

BF9216 100 ug
EUR 438

eNOS Mouse mAb

BF9300 100 ug
EUR 438

P65 Mouse mAb

BF9302 100 ug
EUR 438

cox2 Mouse mAb

BF9303 100 ug
EUR 438

p53 Mouse mAb

BF9304 100 ug
EUR 438

NSE Mouse mAb

BF9305 100 ug
EUR 438

LRIG1, Mouse Recombinant

P1557-10 10 µg
EUR 156

Conclusions: This case expands the phenotype of MPEG1 deficiency to include severe skin infection and soft tissues. We have shown that perforine-2 has reduced the bactericidal capacity of human phagocytes. Interferon-Gamma therapy increases performance of performance-2, which can compensate for such variants. Thus, treatment with IFN-γ could help prevent infections.

 

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