STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells

STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells

Objective: Intrarenal interferon-γ contributed significantly to the development of glomerular injury in which angiotensinogen and monocyte chemoattractant protein 1 levels were high. However, the exact nature of the role played by interferon-γ in regulating angiotensinogen and monocyte chemoattractant protein 1 expression has not been fully described. Therefore, the aim of this study was to investigate the role played by interferon-γ in angiotensinogen and monocyte chemoattractant protein 1 expression.


Methods: Primary cultured rat mesangial cells treated with 0-20 ng / mL interferon-γ for 2, 8 or 24 hours. angiotensinogen expression levels, monocyte chemoattractant protein 1, suppressor of cytokine signaling 1, suppressing the intracellular Janus kinase-signal transducer and activator of transcription signaling and activity of Janus kinase-signal transducer and activator of transcription pathway was evaluated by reverse transcriptase polymerase chain reaction and Western blot analysis.


Results:
Interferon-γ increase the expression of angiotensinogen in mesangial cells was observed following the augmentation maximum 5 ng / mL interferon-γ at 8 hours of treatment (1.87 ± 0.05, mRNA, relative ratio). further increases reduced or no use of higher concentrations of interferon-γ. Following treatment, monocyte chemoattractant protein 1 expression is induced by a linear dose-dependent manner (6.85 ± 0.62-fold at 20 ng / mL interferon-γ at 24 hours). In addition, interferon-γ induced STAT1 phosphorylation and suppressor of cytokine signaling 1 expression with a linear dose-dependent manner.

Oppression STAT1 and suppressor of cytokine signaling 1 expression by small interference RNA angiotensinogen facilitated increased expression of interferon-γ-induced, suggesting that these two factors negatively regulate the expression of angiotensinogen. Conversely, an increase in interferon-γ-induced monocyte chemoattractant protein 1 expression was attenuated in STAT1-deficient mesangial cells, suggesting that STAT1 positively regulates monocyte chemoattractant protein 1 expression in mesangial cells.


Conclusion: These results indicate that while interferon-γ improve both angiotensinogen and monocyte chemoattractant protein 1 expression, STAT1 opponent played a role in the regulation of each of the factors in mesangial cells.

STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells
STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells

Interferon and virus induces novel primate-specific isoform dACE2 and not SARS-CoV-2 receptor ACE2

acute respiratory syndrome-2 coronavirus (SARS-CoV-2), which causes COVID-19, take advantage of the angiotensin-converting enzyme 2 (ACE2) to enter the target cells. ACE2 has been proposed as interferon-stimulated genes (ISG). Thus, the interferon-induced variability in the level of ACE2 expression may be important for susceptibility to COVID-19 or its results. Here, we report the discovery of a new isoform, primate-specific ACE2, which we refer to as deltaACE2 (dACE2).

We show that dACE2, but not ACE2, the ISG. In vitro, dACE2, which has 356 amino acid N-terminal, is non-functional in binding of SARS-CoV spike protein-2 and as Karboksipeptidase A. Our results reconcile the current knowledge on the expression of ACE2 and suggested that the ISG-type induction dACE2 IFN-high in the conditions created by the treatment, the inflammatory tumor microenvironment, or virus co-infection is unlikely to affect the cellular influx of SARS-CoV-2 and promote infection.

human interferon-stimulated protein,ISP ELISA Kit

YLA2196HU-48T 48T
EUR 435

human interferon-stimulated protein,ISP ELISA Kit

YLA2196HU-96T 96T
EUR 562.5

Human Interferon-stimulated gene 20 kDa protein (ISG20) ELISA Kit

RK08672 96T
EUR 280

Human ISG20/ Interferon-stimulated gene 20 kDa protein ELISA Kit

E1339Hu 1 Kit
EUR 685.2

Human Interferon-stimulated Gene 15 Recombinant Protein C-6 His Tag

IHUISG15RC6HIS50UG each
EUR 479
Description: Human Interferon-stimulated Gene 15 Recombinant Protein C-6 His Tag

Human Interferon-Stimulated 20 KDa Exonuclease-Like 2 (ISG20L2) ELISA Kit

abx388035-96tests 96 tests
EUR 1093.2

Human Interferon-gamma

90162-A 20 µg
EUR 130
Description: Recombinant Interferon gamma is a disulfide-linked monomer protein consisting of 144 amino acid residues, and migrates as an approximately 17 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interferon-gamma mature chain was expressed in E. coli.

Human Interferon-gamma

90162-B 100 µg
EUR 205
Description: Recombinant Interferon gamma is a disulfide-linked monomer protein consisting of 144 amino acid residues, and migrates as an approximately 17 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interferon-gamma mature chain was expressed in E. coli.

Human Interferon-γ (IFN-γ) ELISA Kit

CRS-A017 96tests
EUR 535
Description: ClinMaxTM ELISA Kit is convenient ready-to-use immunoassay Kit, specifically designed to quantitate human IFN-gamma that is present in complex biological samples, such as human serum, plasma, and cell culture supernates. A comprehensive validation of the ELISA method was performed following the ICH M10 on bioanalytical method validation and the FDA’s bioanalytical method validation guidance for industry. This validation included assessments of linearity, accuracy, precision, dilution linearity, recovery, and the hook effect. For details information, please refer to the DS. ClinMax™ ELISA Kits are manufactured in a GMP-certified facility and comply to the ISO 13485 standard, ensuring a high level of quality and reliability.

Human Interferon β ELISA kit

E01I0344-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Interferon β in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon β ELISA kit

E01I0344-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Interferon β in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon β ELISA kit

E01I0344-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Interferon β in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon-alpha 2a

90158-A 20 µg
EUR 130
Description: Recombinant Interferon alpha 2a is a disulfide-linked monomeric protein consisting of 166 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interferon-alpha mature chain was expressed in E. coli.

Human Interferon-alpha 2a

90158-B 100 µg
EUR 205
Description: Recombinant Interferon alpha 2a is a disulfide-linked monomeric protein consisting of 166 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interferon-alpha mature chain was expressed in E. coli.

Human Interferon-alpha 2b

90159-A 20 µg
EUR 130
Description: Recombinant Interferon-alpha 2b is a disulfide-linked monomeric protein consisting of 166 amino acid residues. Interefron alpha 2b migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interferon-alpha mature chain was expressed in E. coli.

Human Interferon-alpha 2b

90159-B 100 µg
EUR 205
Description: Recombinant Interferon-alpha 2b is a disulfide-linked monomeric protein consisting of 166 amino acid residues. Interefron alpha 2b migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interferon-alpha mature chain was expressed in E. coli.

Human Interferon gamma (IFNG)

1-CSB-YP011050HU
  • EUR 703.20
  • EUR 358.80
  • EUR 2606.40
  • EUR 1080.00
  • EUR 1730.40
  • EUR 458.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon gamma(IFNG) expressed in Yeast

Human Interferon gamma (IFNG)

1-CSB-EP011050HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon gamma(IFNG) expressed in E.coli

Recombinant Human Interferon-γ

CC117-020 20ug
EUR 351.6

Recombinant Human Interferon-γ

CC117-100 100ug
EUR 489.6

Recombinant Human Interferon-γ

CC117-101 1mg
EUR 3300

Human Interferon β1b ELISA kit

E01I0050-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Interferon β1b in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon β1b ELISA kit

E01I0050-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Interferon β1b in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon β1b ELISA kit

E01I0050-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Interferon β1b in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon β1a ELISA kit

E01I0456-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Interferon β1a in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon β1a ELISA kit

E01I0456-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Interferon β1a in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon β1a ELISA kit

E01I0456-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Interferon β1a in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon ω1 ELISA kit

E01I0765-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Interferon ω1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon ω1 ELISA kit

E01I0765-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Interferon ω1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon ω1 ELISA kit

E01I0765-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Interferon ω1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon ?,IFN-? ELISA Kit

201-12-0066 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interferon ?,IFN-? ELISA Kit

201-12-0077 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interferon ? ,IFN-? ELISA Kit

201-12-0106 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Interferon-stimulated Gene 15 Recombinant Protein

92-169 0.05 mg
EUR 437.1
Description: Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. ISG15 becomes conjugated to a diverse set of proteins after IFN-alpha/beta stimulation or microbial challenge. The functions or biochemical consequences ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation. ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. Upon interferon treatment, ISG15 can be detected in both free and conjugated forms, and is secreted from monocytes and lymphocytes where it can function as a cytokine. In the cell, ISG15 co-localizes with intermediate filaments and ISGylation may modulate the JAK-STAT pathway or certain aspects of neurological disease.

Human Interferon Beta ELISA Kit

IHUIFNBKT each
EUR 507
Description: Human Interferon Beta ELISA Kit

Human Interferon epsilon (IFNE)

1-CSB-EP803137HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon epsilon(IFNE) expressed in E.coli

Interferon-Stimulated Gene 20 kDa Protein (ISG20) Antibody

abx234404-100ug 100 ug
EUR 610.8

Interferon-Stimulated Gene 20 kDa Protein (ISG20) Antibody

abx028929-400ul 400 ul
EUR 627.6

Interferon-Stimulated Gene 20 kDa Protein (ISG20) Antibody

abx028929-80l 80 µl
EUR 343.2

Interferon-Stimulated Gene 20 kDa Protein (ISG20) Antibody

20-abx123522
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Human Interferon gamma ELISA kit

55R-IB49628 96 wells
EUR 1312.8
Description: ELISA kit for the detection of Interferon gamma in the research laboratory

Human Interferon omega ELISA kit

55R-IB49632 96 wells
EUR 1312.8
Description: ELISA kit for the detection of Interferon omega in the research laboratory

Human Interferon alpha-2 (IFNA2)

1-CSB-EP360706HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-2(IFNA2) expressed in E.coli

Human Interferon alpha-2 (IFNA2)

1-CSB-YP360706HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-2(IFNA2) expressed in Yeast

Human Interferon alpha-4 (IFNA4)

1-CSB-EP011040HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-4(IFNA4),partial expressed in E.coli

Human Interferon alpha-6 (IFNA6)

1-CSB-EP011042HU
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-6(IFNA6) expressed in E.coli

Human Interferon alpha ELISA kit

E01I0343-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Interferon alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon alpha ELISA kit

E01I0343-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Interferon alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon alpha ELISA kit

E01I0343-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Interferon alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon Gamma ELISA Kit

IHUIFGKT each
EUR 627
Description: Human Interferon Gamma ELISA Kit

Human Interferon Alpha ELISA Kit

IHUIFNAKT each
EUR 440
Description: Human Interferon Alpha ELISA Kit

Human Interferon Gamma ELISA Kit

IHUIFNGKT each
EUR 355
Description: Human Interferon Gamma ELISA Kit

Human Interferon gamma Protein

abx060793-20ug 20 ug
EUR 343.2

Mouse Interferon-stimulated gene 20 kDa protein (ISG20) ELISA Kit

RK08673 96T
EUR 280

Human Interferon γ , IFN-γ ELISA Kit

CSB-E04577h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interferon γ , IFN-γ in samples from serum, cell culture supernates, urine, tissue homogenates, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interferon γ , IFN-γ ELISA Kit

1-CSB-E04577h
  • EUR 867.60
  • EUR 5859.60
  • EUR 3109.20
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interferon γ , IFN-γ in samples from serum, cell culture supernates, urine, tissue homogenates, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interferon γ ,IFN-γ ELISA Kit

CN-03188H1 96T
EUR 538.8

Human Interferon γ ,IFN-γ ELISA Kit

CN-03188H2 48T
EUR 358.8

Human Interferon ω,IFN-ω ELISA Kit

CN-03460H1 96T
EUR 529.2

Human Interferon ω,IFN-ω ELISA Kit

CN-03460H2 48T
EUR 349.2

Human Interferon α,IFN-α ELISA Kit

CN-03619H1 96T
EUR 548.4

Human Interferon α,IFN-α ELISA Kit

CN-03619H2 48T
EUR 367.2

Human Interferon α, IFN-α ELISA Kit

CSB-E08636h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interferon α, IFN-α in samples from serum, plasma, cell culture supernates, urine, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interferon α, IFN-α ELISA Kit

1-CSB-E08636h
  • EUR 813.60
  • EUR 5572.80
  • EUR 2960.40
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interferon α, IFN-α in samples from serum, plasma, cell culture supernates, urine, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interferon ω(IFN-ω)ELISA Kit

GA-E0105HM-48T 48T
EUR 346.8

Human Interferon ω(IFN-ω)ELISA Kit

GA-E0105HM-96T 96T
EUR 559.2

Human Interferon α(IFN-α)ELISA Kit

GA-E0116HM-48T 48T
EUR 346.8

Human Interferon α(IFN-α)ELISA Kit

GA-E0116HM-96T 96T
EUR 559.2

Human Interferon γ(IFN-γ)ELISA Kit

GA-E0145HM-48T 48T
EUR 346.8

Human Interferon γ(IFN-γ)ELISA Kit

GA-E0145HM-96T 96T
EUR 559.2

Human Interferon ω(IFN-ω)ELISA Kit

QY-E04374 96T
EUR 480

Human Interferon γ(IFN-γ)ELISA Kit

QY-E04386 96T
EUR 433.2

Human Interferon α(IFN-α)ELISA Kit

QY-E04440 96T
EUR 433.2

Human Interferon γ (IFN-γ) ELISA Kit

EKC40056-48T 48T
EUR 474.04

Human Interferon γ (IFN-γ) ELISA Kit

EKC40056-5x96T 5x96T
EUR 3216.7

Human Interferon γ (IFN-γ) ELISA Kit

EKC40056-96T 96T
EUR 677.2

Human Interferon α,IFN-α ELISA Kit

EKC40489-48T 48T
EUR 439.25

Human Interferon α,IFN-α ELISA Kit

EKC40489-5x96T 5x96T
EUR 2980.63

Human Interferon α,IFN-α ELISA Kit

EKC40489-96T 96T
EUR 627.5

Human Interferon ω,IFN-ω ELISA Kit

YLA0666HU-48T 48T
EUR 435

Human Interferon ω,IFN-ω ELISA Kit

YLA0666HU-96T 96T
EUR 562.5

Human Interferon α,IFN-α ELISA Kit

SL0957Hu 96 Tests
EUR 468

Human Interferon ω,IFN-ω ELISA Kit

SL0961Hu 96 Tests
EUR 468

Human Interferon 1 (IFN-1) ELISA Kit

RK08369 96T
EUR 280

Human Interferon γ (IFN-γ) ELISA Kit

RK10061 96T
EUR 280

Human Interferon ω(IFN-ω) ELISA Kit

NSL1961Hu 96 wells
EUR 468

Human Interferon Beta (IFNb) CLIA Kit

20-abx491249
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Interferon ?,IFN-?/IFNB ELISA Kit

201-12-0155 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interferon alpha-1/13 (IFNA1)

1-CSB-EP365592HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-1/13(IFNA1) expressed in E.coli

Human Interferon Alpha 21 ELISA kit

E01I0048-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Interferon Alpha 21 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon Alpha 21 ELISA kit

E01I0048-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Interferon Alpha 21 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon Alpha 21 ELISA kit

E01I0048-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Interferon Alpha 21 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human Interferon beta

EK1511 96 tests
EUR 542.4
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Interferon beta in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Interferon Alpha 10 ELISA Kit

IHUIFNA10KT each
EUR 639
Description: Human Interferon Alpha 10 ELISA Kit

Human Interferon Alpha 21 ELISA Kit

IHUIFNA21KT each
EUR 639
Description: Human Interferon Alpha 21 ELISA Kit

Human Interferon Alpha 2 ELISA Kit

IHUIFNA2KT each
EUR 573
Description: Human Interferon Alpha 2 ELISA Kit

Human Interferon Alpha 4 ELISA Kit

IHUIFNA4KT each
EUR 573
Description: Human Interferon Alpha 4 ELISA Kit

Human Interferon-γ (IFN-γ) ELISA Assay Pair

CRS-D001 5plates
EUR 374.5
Description: Cytokine storm syndromes is an activation cascade of pro-inflammatory cytokines,such as TNF-α,IL-1,IL-6,IL-12,IFN-α,IFN-β,IFN-γ,MCP-1 and IL-8,due to unregulated host immune response system to different stimuli such as infections, malignancy, rheumatoid disorders, drugs, and so on. Interferon-γ (IFN-γ), one of the four subclasses ofinterferons, and is a multipotent protein, acting on many cell types by inducing or inhibiting many cellular functions through direct effects on gene expression. This ELISA assay pair contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant human IFN-γ.

Human Interferon gamma Antibody

R30104 100 ug
EUR 356.15
Description: Interferon-gamma(IFN-gamma) is an inflammatory cytokine that has been implicated in the development of fibrosis in inflamed tissues. The production of IFN-gamma, which is under genetic control, can influence the development of fibrosis in lung allografts. IFN-gamma is also produced by natural killer(NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Interferon gamma is believed to be crucial for host defence against many infections. Genetically determined variability in IFN-gamma and expression might be important for the development of tuberculosis. IFN-gamma activates human macrophage oxidative metabolism and antimicrobial activity. In addition to having antiviral activity, IFN-gamma has important immunoregulatory functions. IFN-gamma plays an important role in the control of neointima proliferation.

Human Interferon Beta (IFN-b) CLIA Kit

abx195799-96tests 96 tests
EUR 990

Human Interferon γ-IFN-γ ELISA Kit

SL0960Hu 96 Tests
EUR 468

IFN beta 1b, Interferon beta 1b, human

RC217-16 2ug
EUR 125.26

Human Interferon Beta (IFNb) ELISA Kit

20-abx152004
  • EUR 7407.60
  • EUR 3949.20
  • EUR 924.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Interferon Alpha (IFNa) CLIA Kit

20-abx190043
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Interferon Gamma (IFNg) CLIA Kit

20-abx190050
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Interferon Beta (IFNb) ELISA Kit

abx253454-96tests 96 tests
EUR 801.6

Human Interferon Beta (IFNb) ELISA Kit

abx576146-96tests 96 tests
EUR 801.6

Human Interferon Beta (IFNb) ELISA Kit

DLR-IFNb-Hu-48T 48T
EUR 465.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Interferon Beta (IFNb) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

DLR-IFNb-Hu-96T 96T
EUR 595.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Interferon Beta (IFNb) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interferon Beta ELISA Kit (IFNb)

RK01630 96 Tests
EUR 625.2

Human Interferon Beta (IFNb) ELISA Kit

RDR-IFNb-Hu-48Tests 48 Tests
EUR 469.2

Human Interferon Beta (IFNb) ELISA Kit

RDR-IFNb-Hu-96Tests 96 Tests
EUR 645.6

Human Interferon Beta (IFNb) ELISA Kit

RD-IFNb-Hu-48Tests 48 Tests
EUR 450

Human Interferon Beta (IFNb) ELISA Kit

RD-IFNb-Hu-96Tests 96 Tests
EUR 618

Human Interferon Beta (IFNb) ELISA Kit

RDR-IFNb-Hu-48T 48T
EUR 328.34
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

RDR-IFNb-Hu-96T 96T
EUR 469.04
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

DL-IFNb-Hu 96T
EUR 305
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

DLR-IFNb-Hu 96T
EUR 320
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

RD-IFNb-Hu-48T 48T
EUR 312.7
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

RD-IFNb-Hu-96T 96T
EUR 446.7
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Interferon Gamma (IFNg)CLIA Kit

SCA049Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interferon Gamma (IFNg) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Human Interferon Gamma (IFNg)CLIA Kit

SCA049Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interferon Gamma (IFNg) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Human Interferon Gamma (IFNg)CLIA Kit

SCA049Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interferon Gamma (IFNg) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Human Interferon Gamma (IFNg)CLIA Kit

SCA049Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interferon Gamma (IFNg) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Human Interferon Gamma (IFNg) CLIA Kit

4-SCA049Hu
  • EUR 6837.60
  • EUR 3673.20
  • EUR 896.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Interferon Gamma (IFNg)Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Human Interferon Beta (IFNb) ELISA Kit

SEA222Hu-10x96wellstestplate 10x96-wells test plate
EUR 4578.24
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interferon Beta (IFNb) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

SEA222Hu-1x48wellstestplate 1x48-wells test plate
EUR 482.21
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interferon Beta (IFNb) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

SEA222Hu-1x96wellstestplate 1x96-wells test plate
EUR 637.44
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interferon Beta (IFNb) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

SEA222Hu-5x96wellstestplate 5x96-wells test plate
EUR 2508.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interferon Beta (IFNb) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Interferon Beta (IFNb) ELISA Kit

4-SEA222Hu
  • EUR 4639.20
  • EUR 2449.20
  • EUR 638.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Interferon Beta (IFNb) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Interferon Alpha (IFNa)CLIA Kit

SCA033Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interferon Alpha (IFNa) in serum, plasma and other biological fluids.

Human Interferon Alpha (IFNa)CLIA Kit

SCA033Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interferon Alpha (IFNa) in serum, plasma and other biological fluids.

Human Interferon Alpha (IFNa)CLIA Kit

SCA033Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interferon Alpha (IFNa) in serum, plasma and other biological fluids.

Human Interferon Alpha (IFNa)CLIA Kit

SCA033Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interferon Alpha (IFNa) in serum, plasma and other biological fluids.

Human Interferon Alpha (IFNa) CLIA Kit

4-SCA033Hu
  • EUR 6837.60
  • EUR 3673.20
  • EUR 896.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Interferon Alpha (IFNa)Serum, plasma and other biological fluids

Human Interferon Alpha (IFNa) CLIA Kit

EKN50543-48T 48T
EUR 414.89

Human Interferon Alpha (IFNa) CLIA Kit

EKN50543-5x96T 5x96T
EUR 2815.33

Human Interferon Alpha (IFNa) CLIA Kit

EKN50543-96T 96T
EUR 592.7

Human Interferon Gamma (IFNg) CLIA Kit

EKN50551-48T 48T
EUR 414.89

Human Interferon Gamma (IFNg) CLIA Kit

EKN50551-5x96T 5x96T
EUR 2815.33

Human Interferon Gamma (IFNg) CLIA Kit

EKN50551-96T 96T
EUR 592.7

Human Interferon Beta (IFNb) ELISA Kit

EKN52259-48T 48T
EUR 331.94

Human Interferon Beta (IFNb) ELISA Kit

EKN52259-5x96T 5x96T
EUR 2252.45

Human Interferon Beta (IFNb) ELISA Kit

EKN52259-96T 96T
EUR 474.2

Human Interferon Alpha (IFNa) CLIA Kit

EKU09432-48T 48T
EUR 666.82

Human Interferon Alpha (IFNa) CLIA Kit

EKU09432-5x96T 5x96T
EUR 4524.85

Human Interferon Alpha (IFNa) CLIA Kit

EKU09432-96T 96T
EUR 952.6

Human Interferon Gamma (IFNg) CLIA Kit

EKU09440-48T 48T
EUR 666.82

Human Interferon Gamma (IFNg) CLIA Kit

EKU09440-5x96T 5x96T
EUR 4524.85

Human Interferon Gamma (IFNg) CLIA Kit

EKU09440-96T 96T
EUR 952.6

Human Interferon Beta (IFNb) ELISA Kit

EKU05091-48T 48T
EUR 444.5

Human Interferon Beta (IFNb) ELISA Kit

EKU05091-5x96T 5x96T
EUR 3016.25

Human Interferon Beta (IFNb) ELISA Kit

EKU05091-96T 96T
EUR 635

Human Interferon Beta (IFNb) ELISA Kit

EKU11148-48T 48T
EUR 533.75

Human Interferon Beta (IFNb) ELISA Kit

EKU11148-5x96T 5x96T
EUR 3621.88

Human Interferon Beta (IFNb) ELISA Kit

EKU11148-96T 96T
EUR 762.5

Human Interferon Beta (IFNb) ELISA Kit

EKN46202-48T 48T
EUR 302.61

Human Interferon Beta (IFNb) ELISA Kit

EKN46202-5x96T 5x96T
EUR 2053.43

Human Interferon Beta (IFNb) ELISA Kit

EKN46202-96T 96T
EUR 432.3

Human Interferon Beta (IFNb) ELISA Kit

EKL61734-5x96T 5x96T
EUR 2673.78

Human Interferon Beta (IFNb) ELISA Kit

EKL61734-96T 96T
EUR 562.9

Human Interferon Beta (IFNb) Protein

20-abx067345
  • EUR 910.80
  • EUR 360.00
  • EUR 2865.60
  • EUR 1095.60
  • EUR 644.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Interferon Beta (IFNb) Protein

20-abx067350
  • EUR 910.80
  • EUR 360.00
  • EUR 2865.60
  • EUR 1095.60
  • EUR 644.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Interferon Alpha (IFNA) Enzyme

abx077007-01ml 0.1 ml
EUR 560.4

Human Interferon alpha 2b Antibody

33488-05111 150 ug
EUR 313.2

Human Interferon alpha-10 (IFNA10)

1-CSB-YP011033HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-10(IFNA10) expressed in Yeast

Human Interferon alpha-14 (IFNA14)

1-CSB-YP011035HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-14(IFNA14) expressed in Yeast

Human Interferon alpha-21 (IFNA21)

1-CSB-YP011039HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-21(IFNA21) expressed in Yeast

Human Interferon alpha-10 (IFNA10)

1-CSB-EP011033HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-10(IFNA10) expressed in E.coli

Human Interferon alpha-14 (IFNA14)

1-CSB-EP011035HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-14(IFNA14) expressed in E.coli

Human Interferon alpha-14 (IFNA14)

1-CSB-EP011035HUe0
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-14(IFNA14) expressed in E.coli

Human Interferon alpha-21 (IFNA21)

1-CSB-EP011039HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interferon alpha-21(IFNA21) expressed in E.coli

Human Interferon γ (IFNγ ) ELISA kit

E01I0345-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Interferon γ (IFNγ ) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon γ (IFNγ ) ELISA kit

E01I0345-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Interferon γ (IFNγ ) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interferon γ (IFNγ ) ELISA kit

E01I0345-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Interferon γ (IFNγ ) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

IFN gamma, Interferon gamma, human

RC217-17 20ug
EUR 125.26

IFN omega, Interferon omega, human

RC217-20 100ug
EUR 203.56

Human Interferon Alpha (IFN-a) CLIA Kit

abx197177-96tests 96 tests
EUR 990

Human Interferon Gamma (IFN-γ) CLIA Kit

abx195803-96tests 96 tests
EUR 990

Human Interferon beta (IFN-β) ELISA Kit

KTE62921-96T5 96 T×5
EUR 2809
Description: Human Interferon beta (IFN-β) ELISA Kit employs a two-site sandwich ELISA to quantitate IFN-β in samples.

Human Interferon beta (IFN-β) ELISA Kit

KTE62921-96T50 96 T×50
EUR 26209
Description: Human Interferon beta (IFN-β) ELISA Kit employs a two-site sandwich ELISA to quantitate IFN-β in samples.

Human Interferon Beta (IFN-β) ELISA Kit

NSL1964Hu 96 wells
EUR 468

Human Interferon Alpha (IFNa) ELISA Kit

20-abx151999
  • EUR 6618.00
  • EUR 3536.40
  • EUR 830.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Interferon Gamma (IFNg) ELISA Kit

20-abx152005
  • EUR 6373.20
  • EUR 3404.40
  • EUR 801.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Interferon Gamma (IFNg) ELISA Kit

abx250933-96tests 96 tests
EUR 801.6

Human Interferon Alpha (IFNa) ELISA Kit

abx252653-96tests 96 tests
EUR 764.4

Human Interferon Kappa (IFNK) ELISA Kit

abx250221-96tests 96 tests
EUR 764.4

Human Interferon Gamma (IFNg) ELISA Kit

abx574392-96tests 96 tests
EUR 801.6

Human Interferon, Gamma, IFNG ELISA Kit

DEIA119 15 Plates
EUR 2889.6
Description: Human IFN-γ ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant IFN-γ in a sandwich ELISA format within the range of 80-1,600 pg/mL. Using the ELISA protocol described below, this kit provides sufficient reagents to assay IFN-γ in approximately 1,500 ELISA plate wells.

Human Interferon, Gamma, IFNG ELISA Kit

DEIA182 96T
EUR 888
Description: This assay is a sandwich Enzyme Linked-Immuno-Sorbent Assay(ELISA). It is developed for quantitative ; measurement of Human IFNG in serum, plasma and other biological fluids.


Development and research into new therapies that selectively and effectively destroy tumor cells that overexpress ERBB2 receptor is a pressing task. More recently, research into the use of type I interferon in the treatment of cancer has been intensified.

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