STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells

STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells

Objective: Intrarenal interferon-γ contributed significantly to the development of glomerular injury in which angiotensinogen and monocyte chemoattractant protein 1 levels were high. However, the exact nature of the role played by interferon-γ in regulating angiotensinogen and monocyte chemoattractant protein 1 expression has not been fully described. Therefore, the aim of this study was to investigate the role played by interferon-γ in angiotensinogen and monocyte chemoattractant protein 1 expression.


Methods: Primary cultured rat mesangial cells treated with 0-20 ng / mL interferon-γ for 2, 8 or 24 hours. angiotensinogen expression levels, monocyte chemoattractant protein 1, suppressor of cytokine signaling 1, suppressing the intracellular Janus kinase-signal transducer and activator of transcription signaling and activity of Janus kinase-signal transducer and activator of transcription pathway was evaluated by reverse transcriptase polymerase chain reaction and Western blot analysis.


Results:
Interferon-γ increase the expression of angiotensinogen in mesangial cells was observed following the augmentation maximum 5 ng / mL interferon-γ at 8 hours of treatment (1.87 ± 0.05, mRNA, relative ratio). further increases reduced or no use of higher concentrations of interferon-γ. Following treatment, monocyte chemoattractant protein 1 expression is induced by a linear dose-dependent manner (6.85 ± 0.62-fold at 20 ng / mL interferon-γ at 24 hours). In addition, interferon-γ induced STAT1 phosphorylation and suppressor of cytokine signaling 1 expression with a linear dose-dependent manner.

Oppression STAT1 and suppressor of cytokine signaling 1 expression by small interference RNA angiotensinogen facilitated increased expression of interferon-γ-induced, suggesting that these two factors negatively regulate the expression of angiotensinogen. Conversely, an increase in interferon-γ-induced monocyte chemoattractant protein 1 expression was attenuated in STAT1-deficient mesangial cells, suggesting that STAT1 positively regulates monocyte chemoattractant protein 1 expression in mesangial cells.


Conclusion: These results indicate that while interferon-γ improve both angiotensinogen and monocyte chemoattractant protein 1 expression, STAT1 opponent played a role in the regulation of each of the factors in mesangial cells.

STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells
STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells

Interferon and virus induces novel primate-specific isoform dACE2 and not SARS-CoV-2 receptor ACE2

acute respiratory syndrome-2 coronavirus (SARS-CoV-2), which causes COVID-19, take advantage of the angiotensin-converting enzyme 2 (ACE2) to enter the target cells. ACE2 has been proposed as interferon-stimulated genes (ISG). Thus, the interferon-induced variability in the level of ACE2 expression may be important for susceptibility to COVID-19 or its results. Here, we report the discovery of a new isoform, primate-specific ACE2, which we refer to as deltaACE2 (dACE2).

We show that dACE2, but not ACE2, the ISG. In vitro, dACE2, which has 356 amino acid N-terminal, is non-functional in binding of SARS-CoV spike protein-2 and as Karboksipeptidase A. Our results reconcile the current knowledge on the expression of ACE2 and suggested that the ISG-type induction dACE2 IFN-high in the conditions created by the treatment, the inflammatory tumor microenvironment, or virus co-infection is unlikely to affect the cellular influx of SARS-CoV-2 and promote infection.

Human CellExp? Human CD40/ TNFRSF5, Human recombinant

9230-10
EUR 278

Human CellExp? Human CD40/ TNFRSF5, Human recombinant

9230-50
EUR 724

Human-to-Human Blocking Reagent

HTH008 8 ml
EUR 76

Human-to-Human Blocking Reagent

HTH015 15 ml
EUR 83

Human-to-Human Blocking Reagent

HTH100 100 ml
EUR 245

Human CellExp? CD38, human recombinant

P1014-10
EUR 207

Human CellExp? CD38, human recombinant

P1014-50
EUR 479

Human CellExp? CD45, human recombinant

P1015-10
EUR 251

Human CellExp? CD45, human recombinant

P1015-25
EUR 457

Human CellExp? VSIG4, human recombinant

P1018-10
EUR 207

Human CellExp? VSIG4, human recombinant

P1018-50
EUR 479

Human CellExp? TrkA, human recombinant

P1020-10
EUR 175

Human CellExp? NOV, human recombinant

P1022-10
EUR 196

Human CellExp? NOV, human recombinant

P1022-25
EUR 294

Human CellExp? EGFRvIII, human recombinant

P1082-10
EUR 283

Human CellExp? LOXL2, human recombinant

P1084-10
EUR 153

Human CellExp? LOXL2, human recombinant

P1084-50
EUR 533

Human CellExp? CD83, Human recombinant

P1109-10
EUR 131

Human CellExp? CD83, Human recombinant

P1109-50
EUR 403

Human CellExp? CD160, human recombinant

P1110-10
EUR 142

Human CellExp? CD160, human recombinant

P1110-50
EUR 392

Human CellExp? CNDP1, Human recombinant

P1125-10
EUR 207

Human CellExp? CNDP1, Human recombinant

P1125-50
EUR 838

Human CellExp? VAPB, Human recombinant

P1135-10
EUR 131

Human CellExp? VAPB, Human recombinant

P1135-50
EUR 370

Human CellExp? Transthyretin, Human recombinant

P1138-20
EUR 185

Human CellExp? Transthyretin, Human recombinant

P1138-50
EUR 392

Human CellExp? Sclerostin, human recombinant

P1145-10
EUR 153

Human CellExp? Sclerostin, human recombinant

P1145-50
EUR 533

Human CellExp? SLITRK6, human recombinant

P1146-10
EUR 142

Human CellExp? SLITRK6, human recombinant

P1146-50
EUR 446

Human CellExp? LILRB2, human recombinant

P1147-10
EUR 131

Human CellExp? LILRB2, human recombinant

P1147-50
EUR 403

Human CellExp? ROR1, human recombinant

P1152-10
EUR 142

Human CellExp? ROR1, human recombinant

P1152-50
EUR 446

Human CellExp? DLL3, Human Recombinant

P1165-10
EUR 566

Human CellExp? DLK1, Human Recombinant

P1166-10
EUR 555

Human CellExp? Progranulin, Human Recombinant

4738-10
EUR 305

Human CellExp? Progranulin, Human Recombinant

4738-100
EUR 2273

Human CellExp? Renin, Human Recombinant

6300-10
EUR 164

Human CellExp? Renin, Human Recombinant

6300-100
EUR 784

Human CellExp? Renin, Human Recombinant

6300-50
EUR 501

Human CellExp? EPO, Human Recombinant

6447-10
EUR 539

Human CellExp? EPO, Human Recombinant

6447-50
EUR 1681

Human CellExp? HGF, Human Recombinant

6456-10
EUR 387

Human CellExp? HGF, Human Recombinant

6456-50
EUR 1398

Human CellExp? HGH, Human Recombinant

6457-10
EUR 338

Human CellExp? HGH, Human Recombinant

6457-50
EUR 1213

Human CellExp? Noggin, Human Recombinant

6474-10
EUR 300

Human CellExp? Noggin, Human Recombinant

6474-50
EUR 1072

Human CellExp? SCF, Human Recombinant

6478-10
EUR 343

Human CellExp? SCF, Human Recombinant

6478-50
EUR 1333

Human CellExp? TPO, Human Recombinant

6483-10
EUR 365

Human CellExp? TPO, Human Recombinant

6483-50
EUR 1980

Human CellExp? sCD14, Human Recombinant

7122-10
EUR 142

Human CellExp? sCD14, Human Recombinant

7122-50
EUR 359

Human CellExp? Thrombomodulin, Human Recombinant

7215-10
EUR 240

Human CellExp? Thrombomodulin, Human Recombinant

7215-50
EUR 860

Human CellExp? BAFF, human recombinant

7222-10
EUR 256

Human CellExp? SHH, human recombinant

7223-10
EUR 213

Human CellExp? EGF, human recombinant

7228-10
EUR 294

Human CellExp? ADAM12, human recombinant

7239-10
EUR 256

Human CellExp? DKK3, human recombinant

7243-50
EUR 343

Human CellExp? SPAM1, human recombinant

7247-10
EUR 392

Human CellExp? SPAM1, human recombinant

7247-50
EUR 1164

Human CellExp? UPA, human recombinant

7248-10
EUR 332

Human CellExp? UPA, human recombinant

7248-50
EUR 1104

Human CellExp? Furin, human recombinant

7249-10
EUR 457

Human CellExp? GAD1, human recombinant

7250-10
EUR 316

Human CellExp? PCSK9, human recombinant

7265-20
EUR 408

Human CellExp? LIF, human recombinant

7267-10
EUR 387

Human CellExp? CD36, human recombinant

7371-10
EUR 245

Human CellExp? CD36, human recombinant

7371-50
EUR 697

Human CellExp? CD80, human recombinant

7383-10
EUR 234

Human CellExp? CD80, human recombinant

7383-50
EUR 675

Human CellExp? CD47, human recombinant

7385-10
EUR 278

Human CellExp? TNFRII, human recombinant

7394-10
EUR 256

Human CellExp? SERPIND1, human recombinant

7411-10
EUR 289

Human CellExp? VTCN1, human recombinant

7412-10
EUR 245

Human CellExp? VTCN1, human recombinant

7412-50
EUR 697

Human CellExp? CD23, human recombinant

7435-10
EUR 262

Human CellExp? CD23, human recombinant

7435-50
EUR 718

Human CellExp? TIMP1, human recombinant

7440-10
EUR 305

Human CellExp? EPHB4, human recombinant

7451-100
EUR 718

Human CellExp? EPHB4, human recombinant

7451-20
EUR 272

Human CellExp? TFPI, human recombinant

7453-10
EUR 283

Human CellExp? CD147, human recombinant

7455-10
EUR 245

Human CellExp? CD147, human recombinant

7455-50
EUR 697

Human CellExp? CD155, human recombinant

7462-10
EUR 245

Human CellExp? CD155, human recombinant

7462-50
EUR 697

Human CellExp? VLDLR, human recombinant

7464-10
EUR 245

Human CellExp? VLDLR, human recombinant

7464-50
EUR 697

Human CellExp? CADM1, human recombinant

7465-10
EUR 245

Human CellExp? CADM1, human recombinant

7465-50
EUR 697

Human CellExp? Transferrin, human recombinant

7467-100
EUR 751

Human CellExp? Transferrin, human recombinant

7467-20
EUR 278

Human CellExp? FOLR2, human recombinant

7471-10
EUR 234

Human CellExp? FOLR2, human recombinant

7471-50
EUR 669

Human CellExp? LDLR, human recombinant

7472-10
EUR 300

Human CellExp? LDLR, human recombinant

7472-50
EUR 827

Human CellExp? TFPI2, human recombinant

7481-10
EUR 300

Human CellExp? RBP4, human recombinant

7563-10
EUR 311

Human CellExp? RBP4, human recombinant

7563-50
EUR 865

Human CellExp? UNC5B, human recombinant

7576-10
EUR 272

Human CellExp?CD4, human recombinant

7834-100
EUR 718

Human CellExp?CD4, human recombinant

7834-20
EUR 267

Human CellExp? TIGIT, human recombinant

8015-10
EUR 349

Human CellExp? Azurocidin, human recombinant

8017-20
EUR 267

Human CellExp? CD163, Human recombinant

9226-10
EUR 305

Human CellExp? CD163, Human recombinant

9226-50
EUR 773

Human CellExp? BTLA, Human recombinant

9228-10
EUR 289

Human CellExp? BTLA, Human recombinant

9228-50
EUR 735

Human CellExp? CD28, Human recombinant

9237-10
EUR 224

Human CellExp? CD28, Human recombinant

9237-100
EUR 724

Human CellExp? CD19, Human recombinant

9246-10
EUR 267

Human CellExp? CD19, Human recombinant

9246-25
EUR 457

Human CellExp? PTPRD, Human Recombinant

P1184-10
EUR 153

Human CellExp? PTPRD, Human Recombinant

P1184-50
EUR 512

Human CellExp? KRAS, Human Recombinant

P1198-10
EUR 142

Human CellExp? KRAS, Human Recombinant

P1198-1000
EUR 2654

Human CellExp? KRAS, Human Recombinant

P1198-250
EUR 892

Human CellExp? KRAS, Human Recombinant

P1198-50
EUR 262

Human CellExp? Hemopexin, Human Recombinant

P1210-10
EUR 196

Human CellExp? Hemopexin, Human Recombinant

P1210-50
EUR 664

Human CellExp? ECE1, Human Recombinant

P1227-10
EUR 251

Human CellExp? ECE1, Human Recombinant

P1227-50
EUR 1012

Human CellExp? CD8b, Human Recombinant

P1244-10
EUR 240

Human CellExp? CD8b, Human Recombinant

P1244-1000 Ask for price

Human CellExp? CD8b, Human Recombinant

P1244-250 Ask for price

Human CellExp? CD8b, Human Recombinant

P1244-50
EUR 805

Human CellExp? ROR2, Human Recombinant

P1254-10
EUR 229

Human CellExp? VEGF110, Human Recombinant

P1258-10
EUR 479

Human CellExp? Prolactin, Human Recombinant

P1311-10
EUR 153

Human CellExp? Prolactin, Human Recombinant

P1311-250 Ask for price

Human CellExp? Prolactin, Human Recombinant

P1311-50
EUR 240

Human CellExp? Dermatopontin, Human Recombinant

P1319-10
EUR 338

Human CellExp? CD177, Human Recombinant

P1410-10
EUR 153

Human CellExp? CD177, Human Recombinant

P1410-50
EUR 392

Human CellExp? PM20D1, Human Recombinant

P1430-10
EUR 403

Human CellExp? DLL3, Human Recombinant

P1463-10
EUR 169

Human CellExp? DLL3, Human Recombinant

P1463-50
EUR 501

Human CellExp? Properdin, Human Recombinant

P1470-10
EUR 164

Human CellExp? Properdin, Human Recombinant

P1470-50
EUR 479

Human, CD79B Human Recombinant Protein, Sf9

PROTP40259-1 Regular: 10ug
EUR 317
Description: CD79B Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 140 amino acids (29-159a.a.) and having a molecular mass of 16.3kDa (Molecular size on SDS-PAGE will appear at approximately 18-28 kDa).;CD79B is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD200 Human Recombinant Protein, sf9

PROTP41217-1 Regular: 10ug
EUR 317
Description: CD200 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 444 amino acids (31-232a.a.) and having a molecular mass of 49.7kDa (Molecular size on SDS-PAGE will appear at approximately 57-70 kDa).;CD200 is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, Lumican Human Recombinant Protein, Sf9

PROTP51884-1 Regular: 10ug
EUR 317
Description: LUM Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 329 amino acids (19-338 aa) and having a molecular mass of 37.7kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).;LUM is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD300C Human Recombinant Protein, Sf9

PROTQ08708-1 Regular: 5ug
EUR 317
Description: CD300C Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 163 amino acids (29-183a.a.) and having a molecular mass of 18kDa (Molecular size on SDS-PAGE will appear at approximately 28-40 kDa). CD300C is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, Noggin Human Recombinant Protein, HEK

PROTQ13253 Regular: 10ug
EUR 317
Description: Noggin Human Recombinant produced in HEK cells is a glycosylated homodimer, having a total molecular weight of 65kDa.;The Noggin is purified by proprietary chromatographic techniques.

Human, Noggin Human Recombinant Protein, Sf9

PROTQ13253-2 Regular: 5ug
EUR 317
Description: Noggin produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 211 amino acids (28-232a.a.) and having a molecular mass of 23.8kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).; Noggin is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, SLAMF1 Human Recombinant Protein, Sf9

PROTQ13291-1 Regular: 10ug
EUR 317
Description: SLAMF1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 226 amino acids (21-237a.a.) and having a molecular mass of 25.3kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).;SLAMF1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, Periostin Human Recombinant Protein, HEK

PROTQ15063-1 Regular: 10ug
EUR 317
Description: Periostin Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Asn22-Gln836) containing a total of 821 amino acids, having a calculated molecular mass of 91.8kDa and fused to a 6 aa His tag at C-Terminus.

Human, CD226 Human Recombinant Protein, Sf9

PROTQ15762-1 Regular: 10ug
EUR 317
Description: CD226 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 471 amino acids (19-247a.a) and having a molecular mass of 53.2kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa)._x000D_ CD226 is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.

Human, SLAMF6 Human Recombinant Protein, sf9

PROTQ96DU3-1 Regular: 10ug
EUR 317
Description: SLAMF6 Human Recombinant produced in Insect cells is a single, glycosylated polypeptide chain containing 214 amino acids (22-226) and having a molecular mass of 24.1kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).;SLAMF6 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

Human, CD244 Human Recombinant Protein, Sf9

PROTQ9BZW8-1 Regular: 10ug
EUR 317
Description: CD244 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 448 amino acids (19-224a.a.) and having a molecular mass of 50.2kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). CD244 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD274 Human Recombinant Protein, Sf9

PROTQ9EP73-1 Regular: 10ug
EUR 317
Description: CD274 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 462 amino acids (19-238a.a.) and having a molecular mass of 52.5kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). CD274 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD84 Human Recombinant Protein, Sf9

PROTQ9UIB8-1 Regular: 10ug
EUR 317
Description: CD84 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 213 amino acids (22-225 a.a.) and having a molecular mass of 23.8kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).;CD84 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD207 Human Recombinant Protein, sf9

PROTQ9UJ71-1 Regular: 10ug
EUR 317
Description: CD207 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 273 amino acids (65-328 a.a.) and having a molecular mass of 30.9kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions). 

Human, Thrombin Human Recombinant Protein, HEK

PROTP00734 Regular: 50ug
EUR 946
Description: Recombinant Human Thrombin produced in HEK cells, having a total molecular weight of 36kDa. ;The Thrombin is purified by proprietary chromatographic techniques.

Human, Renin Human Recombinant Protein, HEK

PROTP00797-1 Regular: 10ug
EUR 317
Description: Renin Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Leu24-Arg406) containing a total of 393 amino acids, having a calculated molecular mass of 43.7kDa and fused to a 10 aa His tag at C-Terminus.

Human, Renin Human Recombinant Protein, sf9

PROTP00797-2 Regular: 5ug
EUR 317
Description: REN Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 391 amino acids (24-406) and having a molecular mass of 43.3kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).;REN is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

Human, Insulin Human Recombinant Protein, Yeast

PROTP01308-1 Regular: 10mg
EUR 317
Description: Insulin Human Recombinant produced in Yeast is a two chain, glycosylated polypeptide chain containing 51 amino acids and having a molecular mass of 5807 Dalton. Zinc content was found to be 0.4%. Insulin is purified by proprietary chromatographic techniques.

Human, CD74 Human Recombinant Protein, Sf9

PROTP04233-1 Regular: 10ug
EUR 317
Description: CD74 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 166 amino acids (73-232a.a.) and having a molecular mass of 19.05kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). CD74 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD5 Human Recombinant Protein, Sf9

PROTP06127-1 Regular: 10ug
EUR 317
Description: CD5 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 359 amino acids (25-372a.a.) and having a molecular mass of 40kDa (Molecular size on SDS-PAGE will appear at approximately 40-57 kDa). CD5 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD2 Human Recombinant Protein, sf9

PROTP06729-2 Regular: 10ug
EUR 317
Description: CD2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 194 amino acids (25-209a.a.) and having a molecular mass of 22.3kDa (Molecular size on SDS-PAGE will appear at approximately 28-40 kDa).;CD2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD14 Human Recombinant Protein, CHO

PROTP08571 Regular: 50ug
EUR 317
Description: The CD14 is produced from human CD14 transfected CHO-cells. Before transfection the complete human CD14-cDNA was amplified by PCR and cloned into expression vector p-POL-DHFR. The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wild type CD14 is the 50-kDa protein containing 335 amino acids and lacks the GPI-Anchor.

Human, CD7 Human Recombinant Protein, Sf9

PROTP09564-1 Regular: 10ug
EUR 317
Description: CD7 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 164 amino acids (26-180a.a.) and having a molecular mass of 17.5kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). CD7 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, Pleiotrophin Human Recombinant Protein, HEK

PROTP13232-1 Regular: 10ug
EUR 317
Description: Pleiotrophin Human Recombinant produced in HEK cells is a non-glycosylated monomer, having a molecular weight of 18kDa.;The Pleiotrophin is purified by proprietary chromatographic techniques.

Human, CD99 Human Recombinant Protein, Sf9

PROTP14209-1 Regular: 10ug
EUR 317
Description: CD99 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 342 amino acids (23-122a.a.) and having a molecular mass of 37.3kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).;CD99 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, LIF Human Recombinant Protein, Yeast

PROTP15018-1 Regular: 25ug
EUR 317
Description: LIF Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 180 amino acids and having a molecular mass of 58.5 kDa. The LIF is purified by proprietary chromatographic techniques.

Human, CD46 Human Recombinant Protein, Sf9

PROTP15529-1 Regular: 10ug
EUR 317
Description: CD46 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 268 amino acids (35-313 aa) and having a molecular mass of 32.5kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).;CD46 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

Human, Endoglin Human Recombinant Protein, Sf9

PROTP17813 Regular: 10ug
EUR 317
Description: CD105 Human Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, Polypeptide containing 586 amino acids and having a molecular mass of 61 kDa but as a result of glycosylation, migrates at 90 kDa under reducing conditions in SDS-PAGE._x000D_ The CD105 is fused to a C-terminal His-tag (6xHis) and purified by proprietary chromatographic techniques.

Human, CD58 Human Recombinant Protein, Sf9

PROTP19256-1 Regular: 10ug
EUR 317
Description: CD58 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 196 amino acids (29-215a.a.) and having a molecular mass of 22.5kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).;CD58 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD27 Human Recombinant Protein, sf9

PROTP26842-1 Regular: 5ug
EUR 317
Description: CD27 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 413 amino acids (21-191a.a.) and having a molecular mass of 46.4kDa (Molecular size on SDS-PAGE will appear at approximately 28-57kDa).;CD27 is fused with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD34 Human Recombinant Protein, Sf9

PROTP28906-2 Regular: 10ug
EUR 317
Description: CD34 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 268 amino acids (32-290a.a.) and having a molecular mass of 28.6kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).;CD34 is fused with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human, CD68 Human Recombinant Protein, 38kDa

PROTP34810 Regular: 5ug
EUR 479
Description: CD68 Human Recombinant full length expressed in E.coli, shows a 38 kDa band on SDS-PAGE.;CD68 is purified by proprietary chromatographic techniques.

Human, CD68 Human Recombinant Protein, sf9

PROTP34810-2 Regular: 10ug
EUR 317
Description: CD68 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 307 amino acids (22-319) and having a molecular mass of 32.6kDa (Molecular size on SDS-PAGE will appear at approximately 57-70kDa).;CD68 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

Human, Myostatin Human Recombinant Protein, Plant

PROTO14793 Regular: 10ug
EUR 317
Description: Myostatin Human Recombinant produced in Nicotiana benthamiana plant is a single chain containing 115 amino acids (molecular formula C586H865N165O164S12) and 6-His-tag at the N-terminal having the total molecular mass of 13.2kDa.

Human, Myostatin Human Recombinant Protein, HEK

PROTO14793-4 Regular: 10ug
EUR 317
Description: Myostatin Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Asn24-Ser375) containing a total of 360 amino acids, having a calculated molecular mass of 41.1kDa. Myostatin is fused to a 2 aa N-terminal linker and a 6 aa His tag at N-Terminus.

Human Alpha-Thrombin (human plasma), purified

TBNA16-N-100 100 ug
EUR 164

Human beta-Thrombin (human plasma), purified

TBNB17-N-100 100 ug
EUR 202

Human Gamma-Thrombin (human plasma), purified

TBNG18-N-250 250 ug
EUR 225

Human CellExp KLF4-TAT, Human Recombinant

P1011-100
EUR 794

Human CellExp KLF4-TAT, Human Recombinant

P1011-20
EUR 229

Human CellExp? B7-H6, human recombinant

P1013-10
EUR 207

Human CellExp? B7-H6, human recombinant

P1013-50
EUR 479

Human CellExp? CLEC3B / Tetranectin, Human recombinant

P1058-10
EUR 153

Human CellExp? CLEC3B / Tetranectin, Human recombinant

P1058-50
EUR 501

Human CellExp? BCMA / TNFRSF17, human recombinant

P1074-10
EUR 147

Human CellExp? BCMA / TNFRSF17, human recombinant

P1074-50
EUR 528

Human CellExp? LTBR /TNFRSF3, Human recombinant

P1111-10
EUR 131


Development and research into new therapies that selectively and effectively destroy tumor cells that overexpress ERBB2 receptor is a pressing task. More recently, research into the use of type I interferon in the treatment of cancer has been intensified.

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